The Open Letters File

Posted 18 November 2007 by

To summarize the recent Open Letters series, some time ago a student of HIV, Ms Smith posted a list of binding sites found in the HIV-1 protein Vpu that contradicted Dr. Behe's assertion that HIV has evolved no new protein-protein binding sites. Central to this was the demonstration that HIV-1 Vpu had evolved into an ion channel, a viroporin. Over two months later, Dr. Behe wrote a response, which did a disservice to Ms Smith on many levels, most especially by ignoring the key argument about Vpu viroporin. I remonstrated with Dr. Behe about this in an Open Letter. Dr. Behe publishing a series of responses to this open letter, which I responded to post by post as they were published. As you may realize, Dr. Behe has finally conceded that he was wrong, and Vpu viroporin represents a real example of protein-protein binding. I have suggested that he issue an erratum to this effect, thanking Ms Smith for bringing this example to his attention (and the HIV Vpx duplication, which he also claimed didn’t exist). This is the very stuff of science, we all at some stage support ideas that were wrong, but when we realize they are wrong, we give them up. I thank Dr. Behe for acknowledging his mistake. Along the way we have also learned that Dr. Behe’s citations don’t actually support his statements in “edge of Evolution”, his estimation of HIV mutation rates and effective population numbers is off by orders of magnitude, and his rationale for excluding viral protein-cellular protein binding has no biological basis (and is inconsistent). For ease of perusal, I have put the links for all the Open Letters into this one post. The Original Open Letter, where I protest at Dr. Behe’s treatment of Ms Smith.
An Open Letter Part 2, where I detail Vpu viroporin and point out that Dr. Behe’s references do not support his assertions.
An Open Letter Part 3, where I chide Dr. Behe for his continuing poor treatment of Ms Smith.
An Open Letter Part 4, where I go into more detail about why Dr. Behe’s attempt to exclude certain binding sites is not valid.
An Open Letter Part 5, where I dig even deeper into binding sites, and show why Dr. Behe’s attempt to exclude certain binding sites is not valid in even more detail.
An Open Letter Part 6, where I point out that Dr. Behe’s population and mutation rate estimates for HIV are wrong by orders of magnitude.
An Open Letter Part 7, where I thank Dr. Behe for admitting he was wrong, point out that “impresessedness” is not a biologically valid standpoint, and show that yet another reason for excluding viral protein-cell protein interactions is invalid.

105 Comments

Bach · 18 November 2007

Way to go Ian, execellent job!

Paul Burnett · 18 November 2007

An excellent piece of scholarship, sir. We thank you.

Mark Perakh · 18 November 2007

Something very unusual happened: having found himself in a corner because of the well substantiated and professionally written Open Letters by Dr. Musgrave, and facing the choice, either to stubbornly continue refusing to admit his mistakes, thus damaging his already seriously damaged reputation even further, or finally admit that the "mere grad student," and "a woman" bested him, Dr. Behe made a step in a right direction. He admitted that he was wrong. I applaud his admission.

While this may serve to partially repair Behe's standing in the scientific community, this must be just the first step. To recover the respect of scientists (rather than of ID advocates) Dr. Behe should (besides an apology to Abbie Smith) finally respond to many other critical comments to his pro-ID work, and admit his errors pointed out by a number of critics. One example is my critique of Behe's treatment of probabilities and complexity (see for example here and here), to which Behe has not been responding for eight years.

The above story shows a possible reason for Behe's ignoring critique such as that I offered: if he likewise simply ignored Abbie's posts, he would not face the hard choice between admitting his error and defending an indefensible position.

For a scientist with many years of work behind him, Behe's 35 scientific publications is not a very impressive record. Now Dr. Behe has an opportunity to respond finally to critique such as that I suggested, to admit that his treatment of probabilities and complexity was inadequate, and return to a biochemical lab for a real research instead of writing books aimed at gaining cheap popularity among general population and an acclaim by the ID crowd. That is the only way he may recover a respectable standing in the scientific community.

David Stanton · 18 November 2007

Congratualtions! Getting Behe to admit that he is wrong about anything is a major accomplishment. We should make sure that this public admission of error is freely available to all who want to see it. We also need to carefully document the lengths that ERV and Ian had to go to in order to get this one grudging admission. Maybe then people will realize that Behe is just as wrong about almost everything else he says as well.

The mere fact that he was wrong about something is not the important thing. As many have pointed out, scientists are wrong about things all the time. The difference is that they are usually not wrong because they made sweeping generalizations in a field they know nothing about and ignored all evidence that contradicted them. They usually admit that they were wrong when the evidence is provided without stooping to name calling and sexist remarks to try to divert attention from the fact that they were simply wrong. One simple rebuttal article is usually enough for a real scientist to admit error, or come up with more evidence in support of his thesis.

The fact that it took this much effort to get Behe to admit that he was wrong about one relatively minor point shows that his arguments are not driven by evidence but by willful ignorance. Why not just admit that this one example was a mistake and that he reaslly isn't an expert in this particular field? Why not stick to the examples in his own field that have solid evidence ... what? ... oh, never mind.

Stanton · 18 November 2007

Now to get him to admit that he was wrong about saying that the immune system couldn't have evolved.

Elf Eye · 18 November 2007

He admitted he was wrong, but in a very grudging and ungracious manner.

Bach · 18 November 2007

I must admit I am having second thoughts...I mean what did Behe do really with his apology??

I mean, you basically have a complex mixture of interacting components inside Behe called traits. These were past from his ancestors. He is simply the end result of an endless number of natural interactions which designed the being you see before you. Evolution wise, they guy was incapable of doing anything else, his genes made the apology happenlong before Behe was born, so were probably giving him way to much credit. Do we thank the ATM machine that gives us our money? No we expect it to perform as design based on its original plan, modified through constant improvement as with the intriduction of new models.
Proteins do much of the chemical work inside Behes' cells, so they largely determine what those traits are. But those proteins owe their existence to Behe's DNA, so that is where we must look for the origins of this apology.

Come to think of it, Behe was barely involved in the apology process, just a speck at the end of a Billion year line leading to the ability to apologize.

Jim Wynne · 18 November 2007

Behe's admission of error doesn't even count, because he also dishonestly stated that the error was not significant to his thesis, when clearly it was. Behe hasn't admitted error where it actually counts, in terms of demonstrating to his acolytes that the entire basis of the book is wrong.

Reynold Hall · 18 November 2007

Unbelievable. They're still defending him

http://www.uncommondescent.com/education/pbs-airs-false-facts-in-its-inherit-the-wind-version-of-the-kitzmiller-trial/

I admit I don't know much (ok, any!) about this topic, but from what I can read, it looks to me like they're just picking nits. That sound about right?

What would it take for thos people to finally admit that they (or their chosen representative) was wrong, and a "darwinian" critic was right?

JGB · 18 November 2007

It would be interesting if we could have some kind of substantive historical comparison between Behe's response to critiques and some other examples of scientists changing their minds about pet theories. I cannot recall who said it, but the notion that long term change in scientific thought requires the passing on of the original proponents of a theory is rather intriguing here. Clearly most scientists are more than willing to change their minds in the face of some good evidence. At the same time most prominent theories due seem to have adherents who cling to the bitter end inspite of evidence nearly everyone else has found more than convincing. I wonder to what extent their is a psychological parallel in the two sets of behavior.

Stanton · 18 November 2007

Reynold Hall: What would it take for thos people to finally admit that they (or their chosen representative) was wrong, and a "darwinian" critic was right?
If God were to tell them, "you were wrong, Darwin was right."

Frank J · 18 November 2007

Not only "grudging and ungracious," but in his 5th and final (?) post, Behe still claims an exception for cellular proteins:

"Cellular proteins must continually exist in a confined space, dense with many other cellular proteins, and so they are normally selected to not bind to most other cellular proteins. In other words, for eons the surfaces of cellular proteins have been honed so as to not interact with almost any other protein in a very concentrated cellular milieu."

That argument would have had me going 10 years ago, which means that even the subset of his target audience that's not hopelessly compartmentalized might give him the point on that round. But the overriding point is that, even if there are no good "before and after" examples of cellular protein changes in a eukaryote lineage (thanks to poor fossilization if cellular compounds), Behe is clear that "impressive" mutations (those beyond the "edge") must have occurred, just by looking at closely related species. So the question everyone should be asking is "Why on earth is he avoiding looking for them and, heaven forbid, testing them?" Even if (combining Dembski's and Nelson's admissions) Behe has no "mechanistic theory," and nothing more than a "bag of powerful intuitions," he should be able to use his calculations to pinpoint when, and in what lineages, those "i-mutations" occurred. Oh, and be clear whether or not they are indeed "design actuation events."

Technical refutations are valuable and necessary, but Behe's complete refusal to elaborate on his ideas, in contrast to his endless elaboration on "Darwinism," is the most devastating argument against them. Second, or maybe tied, is the refusal of Behe and those IDers who appear to think that "i-abiogenesis" occurs in lieu of "i-mutations" to openly debate their differences, as real scientists do.

JGB · 18 November 2007

I read through some of the critiques and if was rather odd to see them saying of course it could have evolved it's got all this population to sacrifice to natural selection? What I find intriguing is that they don't seem to realize that is exactly what has been promoted for years. Given sufficient time populations are able to sample all the sequence space they need to evolve new functions if they are useful.
There claim is the equivalent of saying that in the 200+ dimensions of an enzyme there are no connections between associated areas of functions. Considering that humans really struggle to imagine 1 extra dimension. How would one have enough arrogance to believe that I can accurately reason that these kind of connections between different functions don't exist in sequence space? We've already located numerous examples of close contacts in sequence space. It just so happens that all of the different possibilities make it a rather long term problem to work out every detail.

JGB · 18 November 2007

Stanton I think it would be a mistake to say that, because you could not prove to that person that it was not in fact the devil testing their faith.

raven · 18 November 2007

If God were to tell them, “you were wrong, Darwin was right.”
Naw, wouldn't make a bit of difference. It is almost impossible to turn a crackpot. God has already told them not to lie, that commandment of what used to be the 10 commandments. And not to kill either. They lie constantly and occasionally murder those they disagree with. It's 400 years after Copernicus, we've been to the moon, have robots driving around on Mars, a space probe around Saturn, and a space station in orbit around the earth. 26% of the fundies still believe the sun circles the earth.

Mike Elzinga · 18 November 2007

Come to think of it, Behe was barely involved in the apology process, just a speck at the end of a Billion year line leading to the ability to apologize.
Of course an alternative would be that the “Designer” deliberately designed him to do everything that he did until he got caught by people who were designed to expose him.

SteveF · 18 November 2007

As far as I can tell, the commenters at UD seem to primarily be arguing that this is within the limits of the EoE. For example:

[quote]Don’t fall into Musgrave’s trap of conflating the two examples of minor Darwinian evolution. The whole point is that something like this might be expected to be within the powers of Darwinism for viruses. The problem is that they’re taking the factors surrounding viruses and extrapolating that as somehow providing evidence for higher organisms even though the situation is very different.[/quote]

Bornagain also accuses Ian of dishonesty in his population numbers argument :

[quote]In Musgrave’s attempt to get around Dr. Behe’s hard number of 10^10 for HIV he tries to use the smoke and mirrors of effective population size used in population Genetics. Yet I looked at Behe’ sources in His book and they do in fact take into account the effective population size that is used in population genetics to arrive at there number. So Behe’s number is thoroughly thought out and firm as a rock.[/quote]

Leading to this strong accusation:

[quote]In my opinion this was a desperate attempt at distortion on your part and you should be ashamed to call yourself a scientist, since apparently finding the truth has no meaning for you![/quote]

http://www.uncommondescent.com/education/pbs-airs-false-facts-in-its-inherit-the-wind-version-of-the-kitzmiller-trial/

This "distortion" led bornagain to investigate the binding site that "is so impressed with":

[quote]From my limited knowledge of the subject, it seems the protein/protein binding site he is so excited about, is actually a additional “refining” protein binding site of the one that actually allowed the HIV to gain access to humans in the first place.[/quote]

http://www.uncommondescent.com/education/pbs-airs-false-facts-in-its-inherit-the-wind-version-of-the-kitzmiller-trial/#comment-149133

SteveF · 18 November 2007

Apologies for the messed up quotes!

wamba · 18 November 2007

his rationale for excluding viral protein-cellular protein binding has no biological basis (and is inconsistent).

Two deletion mutations sighted. Evolution at work!

Tyler DiPietro · 18 November 2007

There's some pretty comical comments over at UD. I'll let the biophreaks handle the relevant content, I just have to note this from "Patrick":

"The oddball part is that none of these examples have enough informational bits to be CSI."

And not a calculation in sight, as if we needed another demonstration that CSI was a meaningless catch-phrase used primarily to provide a simulacrum of mathematical legitimacy.

Olorin · 18 November 2007

JGW said[#135635]: "There [sic] claim is the equivalent of saying that in the 200+ dimensions of an enzyme there are no connections between associated areas of functions."
ID wonks enjoy painting mental pictures of "hills" in fitness space that can only be traversed through lower-fitness, thus unselectable, "valleys." In dozens or hundreds of dimensions, however, absolute hilltops are rare to the point of nonexistence. Even if half a dozen dimensions reach a maximum simultaneously, a couple of others are still trending upward. Please, all you biologists, don't let them get away with this inaccurate 3D oversimplification.

(Don't overheat your brains with the visualizations. Even the most hardened mathematicians cannot begin to encompass the 196,883 dimensions of the Monster Group.)

David Stanton · 18 November 2007

"Don’t fall into Musgrave’s trap of conflating the two examples of minor Darwinian evolution. The whole point is that something like this might be expected to be within the powers of Darwinism for viruses. The problem is that they’re taking the factors surrounding viruses and extrapolating that as somehow providing evidence for higher organisms even though the situation is very different."

So, let's see, Behe claims that this is something that viruses just can't do through natural means and therefore he concludes that all of evolution must be wrong. He is shown to be absolutely wrong and the response, well you still haven't proven that anything else can do this. Bite me. You prove that they can't.

Mutations occur in all organisms. All organisms undergo selection. What could possibly stop this type of adaptation from happening in any organism given enough time. The evidence is very clear that indeed it has happened many times. Ignoring the evidence is pure ignorance and stupidity.

Behe claimed that if you couldn't find this type of change in viruses then it would be unlikely that such changes could occur in other organisms. Since he was proven to be wrong, it does not imply by any stretch of logic that anyone has proven that it could not occur in other organisms. Indeed, if it can occur in just a few years in viruses, it is almost inevitable that things like this would occur in other organisms given enough time. No one ever claimed that this proves that it can happen in other organsism, just that the result is consistent with all the other evidence that shows that it in fact did.

When you are proven to be wrong admit it and move on. No one will respect anything else.

Inoculated Mind · 18 November 2007

Yes, I’m perfectly willing to concede that this does appear to be the development of a new viral protein-viral protein binding site, one which I overlooked when writing about HIV.
Doesn't it sound like one of Dembski's Notpologies - he's willing to concede - but doesn't actually? WILLING to concede that this APPEARS to.... doesn't outright say it. Still, it's quite a preparation to concession from an ID creationist.

Teach · 18 November 2007

Could someone please enlighten me as to what, exactly, Behe's "restricted choice" is? As applied to both HIV and malaria,it sounds an awful lot like variation and natural selection to me. The more I read his retractions and corrections, the more his "theory" changes to sound like Darwinian evolution. Pretty soon, I think he'll just back himself into a corner and declare that ID and evolution are compatible and he thought of them both.
Mendelian geneticists watch out - you're next I think. Designer genes and all that.

Back to lurking.

Tyler DiPietro · 18 November 2007

Olorin has just inspired the next Cranks Cluedo post. Thanks Olorin!

Bach · 18 November 2007

If I were a Darwinian evolutionist I might suggest that Behe was passed down the apology trait due to males wanting to mate with females, thus they needed the apology trait in order to get the women to agree to mating.

Thus Behe not so much apologized to Ian, but said he wanted to have sex with him....in an evolutionary sense..

Of course a modern terminology for such an act would be F-ck You! So maybe Behe wasn't apoogizing after all, just speaking in a language a Darwinian Evolutionist would understand.

Tyler DiPietro · 18 November 2007

I suspect that Bach's post can be attributed to repressed fantasies.

JGB · 18 November 2007

That incredibly mature mode of thinking Bach is exactly the same kind of sloppy reasoning that somehow twists natural selection into a theory that "demands" Eugenics. It's OK Bach my school has some opening in it's 7th grade and we teach both Virtue and Logic.

Ian Musgrave · 18 November 2007

Typo's fixed! Thanks folks, I had to write this (and indeed most of the series) late at night after marking exams, so my attention to spelling, even with the help of spell checkers, was not what it could have been.

hoary puccoon · 18 November 2007

JGB--

Famous cases of scientists admitting they were wrong include Arthur Smith Woodward's acceptance of the "Taung Child," Raymond's Dart's skull of a juvenile Australopithicus africanus, as a hominid. It took Woodward a long time, but, fortunately, Dart lived a long time.

Linus Pauling, on the other hand, admitted Watson and Crick's model of DNA was right and his own was wrong even before Watson and Crick's paper was published in Nature.

Richard Leakey took longer to admit the date of 2.9 my for the "1470" skull, discovered in 1972, was wrong. The currently accepted date is 1.8 my. But he did back down eventually. (Bornagain, on the other hand, is still using a Leakey quote from the period when Leakey was defending the older date, although I have now corrected him a total of four times!)

Lord Kelvin hedged his bets when he claimed the earth couldn't be more than some hundreds of thousands of years old, and added something like "unless a completely new form of energy is discovered." So when atomic energy was discovered, nobody had to say the great man was wrong. They called him "prescient!"

But if you really want an example of a scientist backing down on his pet theory, read Francis Crick's "What Mad Pursuit." He practically gloats about some of the things he got wrong. Which may explain why he had such a productive scientific career.

Ian Musgrave · 18 November 2007

Bach's most recent comment has been moved to the Bathroom wall, as will any more content free spamming.

Torbjrn Larsson, OM · 18 November 2007

The problem is that they’re taking the factors surrounding viruses and extrapolating that as somehow providing evidence for higher organisms even though the situation is very different.
The problem was that creationists were "taking factors surrounding viruses and extrapolating that as somehow providing evidence for higher organisms" while pretending that "the situation is very different". Biologists, notably Darwin, observed evolution, developed and provided testable predictions on a theory in the middle of 19th century, way before AFAIU viruses were recognized as fundamentally different (i.e. here: often much smaller) from bacteria in the late 19th century.
Cellular proteins must continually exist in a confined space, dense with many other cellular proteins, and so they are normally selected to not bind to most other cellular proteins. In other words, for eons the surfaces of cellular proteins have been honed so as to not interact with almost any other protein in a very concentrated cellular milieu.
So is that any different from the viral proteins that are produced and interacting in the same environment? I assume even capsid proteins evolved to have limited interaction while being assembled and leaving the cell by transportation or lysis. And if HIV have a fair share of its proteins involved in controlling the cell, it isn't an argument at all.
Joe G wrote: "You are a liar. Page 15 of "The Edge of Evolution", Dr Behe states "The genome of HIV, the virus that causes AIDS, is a minute scrap of RNA, roughly one-millionth the size of the human genome."" That's nice. Unfortunately for you, he claims elsewhere in the book that the genome is DNA. Here's what Behe says on pp. 138-139: " And exactly what has all that evolution of HIV wrought? Very little. . . . Over the years its ***DNA*** sequence has certainly changed. HIV has killed millions of people, fended off the human immune system, and become resistant to whatever drug humanity could throw at it. Yet through all that, there have been no significant basic biochemical changes in the virus at all."
So I eventually found a reference to Behe's edge of knowledge, other errata he should make if he cares, on already infamous EoE.

Olorin · 18 November 2007

Thanks, Tyler, for pointing to this interesting blog. I proposed a "3D Blinders" fallacy as a comment to Cranks Cluedo.

Another subject for someone to add to the Cluedo list concerns abuses of deMoivre's results as to statistical sample sizes. Alas, I am but a lawyer, not a mathematician. See "The Most Dangerous Equation," American Scientist, May-June 2007, pp249-256 for an interesting discussion of sample-size fallacies.

Henry J · 18 November 2007

Behe: "HIV has killed millions of people, fended off the human immune system, and become resistant to whatever drug humanity could throw at it. Yet through all that, there have been no significant basic biochemical changes in the virus at all."

And he thinks people won't notice that those two ( adjacent!! ) sentences contradict each other?

Famous cases of scientists admitting they were wrong

Add to that the constant that Einstein's proposed to keep the universe stable. Also the announcement in 1999 (I think it was) of the detection of element 118 in an experiment, retracted a few months later. (Note- 118 has been detected since then in a different experiment, that afaik still holds. (However, #117 is still missing from the detected elements list, last I heard.) )

Lord Kelvin hedged his bets when he claimed the earth couldn’t be more than some hundreds of thousands of years old, and added something like “unless a completely new form of energy is discovered.”

Yep. When two theories produce seemingly confirmed conclusions that conflict with each other, there's probably something somewhere that's yet to be discovered. (Like quantum gravity, maybe.)

his rationale for excluding viral protein-cellular protein binding has no biological basis (and is inconsistent).

Two deletion mutations sighted. Evolution at work! Nah, that was intelligent design if anything was. ;) Henry

Stanton · 18 November 2007

Actually, Lord Kelvin thought that the world was only a few tens of millions of years old.

trrll · 18 November 2007

There are several aspects of Behe's rebuttal that seem to indicate that his knowledge of cellular physiology is very limited. Perhaps, back in the day when he actually did experimentation, he was one of those biochemists who focused on individual enzymes in vitro without bothering to attempt to understand how they relate to cellular function. For example, he dismisses the channel on the grounds that
Second, the viroporin is not some new molecular machine. There is no evidence that it exerts its effect in, say, an ATP- or energy-dependent manner
This seems to indicate that he is unaware that cells store energy in the form of ionic gradients as well as ATP, by using ATP driven pumps to drive ions across the membrane. Many cellular molecular machines are channels that function in this manner taking advantage of energy stored in ionic gradients--indeed, such channels mediate nerve conduction andfast synaptic signaling, and as are known play a critical role in the human "intelligence" which so impresses Behe. Examples include GABAA receptors, ionotropic glutamate receptors, nicotinic acetylcholine receptors, and calcium and potassium channels of many types. None of these directly use energy in the form of ATP, but only energy stored in transmembrane ion gradients. This is very elementary cellular philosophy. He also insists
This situation is probably best viewed as a foreign protein degrading the integrity of a membrane, rather than performing some positive function.
Yet if he bothered to read the papers cited, he would have seen that the channel in question exhibits selectivity between positive and negative ions. This excludes degradation of the integrity of the membrane, which would not be expected to exhibit ionic selectivity, and argues that a true channel is involved. I also thought that it was amusing that Behe argues
Only one new binding site need develop for one area of a protein which binds to a different area of the same protein, to form a homogeneous complex with, say, C5 symmetry. That is all that is required for a circularly symmetric structure to form.
Behe is, of course, quite right that the evolution of circularly symmetric structures can occur rather easily, but I'm surprised that he would choose to emphasize this fact, considering that the flagellar "motor" is also a circularly symmetric structure.

Joel · 18 November 2007

Best. Scientific. Fisking. Ever.

hoary puccoon · 18 November 2007

I said:

"Lord Kelvin hedged his bets when he claimed the earth couldn’t be more than some hundreds of thousands of years old...."

Stanton said:

"Actually, Lord Kelvin thought that the world was only a few tens of millions of years old."

In the spirit of this thread, I guess I'd better acknowledge my error!

Ian Musgrave · 18 November 2007

SteveF wrote in comment 135639:
Bornagain also accuses Ian of dishonesty in his population numbers argument:
In Musgrave’s attempt to get around Dr. Behe’s hard number of 10^10 for HIV he tries to use the smoke and mirrors of effective population size used in population Genetics. Yet I looked at Behe’s sources in His book and they do in fact take into account the effective population size that is used in population genetics to arrive at there number. So Behe’s number is thoroughly thought out and firm as a rock
Oh, that would be the Rodrigo paper (cited in 15 on page 290 in Behe’s book, PNAS, 1999, 96:10559-61) would it? Where they say:
It has been estimated that the total number of HIV-infected cells in a human host is between 107 and 108 (6). However, only a portion of infected cells produce viable viral particles that go on to infect other cells. … [estimates of infected populations] place the value at around 103 infected cells
and then go on to give other estimates of up to 105 for HIV populations. Same goes for Althaus CL and Bonhoeffer (J Virol, (2005), 79:1313572-78, also listed under 15 in Behe’s book).
The viral population in an infected patient may indeed represent such a population limited in size, since current estimates of the effective population size range from 500 to 105.
They point to some evidence from the rise of resistance in HIV that is consistent with a low effective population compared to the census population. Coffin MJ (Science, 1995, 267:483-89), Behe’s source for the “each and every possible single-point mutation occurs” uses the census population only, they do not account for the effective population. Well, it was an early report, and this incorrect use of the census population was pointed out in a subsequent comment (Levy JA, et al., Science. 1996 Feb 2;271(5249):670-1) noting that “most of these viruses are not infectious”. All evidence points to the fact that double point mutations are not occurring once per day as Behe claims (see also Seo T-K et al., Genetics, Vol. 160, 1283-1293, April 2002, Dr. Behe’s viral replication rates over a humans lifetime seem to be a bit off as well). I would suggest Bornagain brush up on their reading comprehension skills, as it can be clearly shown that Dr. Behe is not using values corrected for effective population size by reference to the very papers Behe cites.

JGB · 18 November 2007

Lord Kelvin is one example I had thought of. Wegner's opponents to continental drift was another one. I confess that I was looking for more depth on the historical issues than I think can be fit into a single post. Particularly with continental drift it's a case of everyone being wrong. I think part of what intrigues me about the issue is that in some cases we laud people for dogged determination to a theory to see it to wide spread acceptance. And in others we are critical of scientists for sticking with a theory as it accumulates uncorrected problems. It strikes me that your probably talking about similar personality traits in both cases, and yet some are heroes and others villans (after a fashion anyway).

Ian Musgrave · 18 November 2007

Reynold Hall wrote in comment 135629
I admit I don't know much (ok, any!) about this topic, but from what I can read, it looks to me like they're just picking nits. That sound about right?
They are not even picking nits, they are combining a breathtaking degree of biological cluelessness with an inability to read basic literature. There is no content there worthy of comment.

Ian Musgrave · 18 November 2007

Teach wrote in comment 135646
Could someone please enlighten me as to what, exactly, Behe's "restricted choice" is? As applied to both HIV and malaria, it sounds an awful lot like variation and natural selection to me. The more I read his retractions and corrections, the more his "theory" changes to sound like Darwinian evolution.
Yes, it’s plain old natural selection, I deal somewhat briefly with this in Open Letter (part 7). Firstly, it’s irrelevant to his argument. His claim is that for any decent binding site to get started, you need three or more simultaneous mutations. That is for any high affinity, selectable binding site. His claim is that the alleged absence of any new binding sites from HIV shows that evolving binding sites must require at least this level or more simultaneous mutations. It is an argument that does not depend on then selectability of the subsequent binding site, but the sheer raw improbability (see Chapter 7, the two binding sites rule, and Behe’s early replies to my Open Letter, which are couched in purely probabilistic terms). Secondly, as I point out in the Open Letter, even this argument is incoherent, viral proteins are under just as much pressure to bind selectively as cellular proteins. To reiterate, a virus’s job is not to kill the cell it invades, but to get the virus safely into the cell, avoid cellular defences, make copies of itself and release new viral particles. Viral particles can’t afford to bind to anything willy-nilly. Willy-nilly binding is far more likely to result in binding to proteins that will cause replication failure, or failure of virus release, as to have a helpful role. Even a virus like SIV, infecting a new host like humans to produce HIV does not get free slather. Human proteins are only marginally different to chimpanzee proteins, so there are very limited new “targets of opportunity”, which HIV proteins cannot bind to willy-nilly anyway.

Brian McEnnis · 18 November 2007

JGB: It would be interesting if we could have some kind of substantive historical comparison between Behe's response to critiques and some other examples of scientists changing their minds about pet theories. I cannot recall who said it, but the notion that long term change in scientific thought requires the passing on of the original proponents of a theory is rather intriguing here. Clearly most scientists are more than willing to change their minds in the face of some good evidence. At the same time most prominent theories due seem to have adherents who cling to the bitter end inspite of evidence nearly everyone else has found more than convincing. I wonder to what extent their is a psychological parallel in the two sets of behavior.
The quote is from Max Planck:
A new scientific truth does not triumph by convincing its opponents and making them see the light, but rather because its opponents eventually die, and a new generation grows up that is familiar with it.
Scientists born 200 years ago may have been excused for clinging to concepts that were the scientific consensus in the early nineteenth century. Behe has no such excuse.

Stanton · 18 November 2007

hoary puccoon: I said: "Lord Kelvin hedged his bets when he claimed the earth couldn’t be more than some hundreds of thousands of years old...." Stanton said: "Actually, Lord Kelvin thought that the world was only a few tens of millions of years old." In the spirit of this thread, I guess I'd better acknowledge my error!
It wasn't that Lord Kelvin hedged his bets, it was that, according to his calculations, if Earth started out as a big ball of molten rock, that 30 to 50 million years would be how long it would take for it to cool down and become solid. Had he lived after the discovery of radioactivity, he would have realized that rock can stay molten for much longer periods of time, i.e. billions of years rather than millions of years, if it was constantly being irradiated.

Dale Husband · 18 November 2007

Intelligent Design is dead and the time has come to bury the rotting corpse. And since ID was also the last attempt to resurrect the zombie of Creationism, dress it up in new clothes and try to make it respectable again, the ID promoters, including Behe, have actually signed the death warrent of the faith of a great many people who may have once beleived in them.

GvlGeologist, FCD · 18 November 2007

Stanton said: Had he lived after the discovery of radioactivity, he would have realized that rock can stay molten for much longer periods of time, i.e. billions of years rather than millions of years, if it was constantly being irradiated.
It's a small point in the context of this discussion, but the problem wasn't how long the earth stayed molten. Kelvin's calculations showed how long (in the absence of other sources of energy) the earth would have taken to cool from an initially molten state. And, after it solidified, the earth would, in fact, have taken a lot longer to cool than Kelvin calculated, due to radioactive energy input.

GvlGeologist, FCD · 18 November 2007

And, in retrospect, I should have said, the earth would have stayed warm much longer than Kelvin calculated, due to radioactive energy input.

Dale Husband · 18 November 2007

Pole Greaser: In light of the sexual practices associated with his particular den of evolutionism this could very well be not too far off the mark! All kidding aside, the Mary-worshiping evolutionist Behe has tried to carve out a space for the true God of the Bible and stumbled upon his own incoherence. His Roman Pagan theology puts on a facade about Jesus while spewing the teachings of Darwin!
As long as you keep saying stupid things like that, you make Creationism all the less credible. Maybe you are on OUR side?

snaxalotl · 19 November 2007

not just a great display of scholarship, but a great display of really nailing someone to the wall over a single issue. Even if it's a peripheral issue, really pinning one of the handwavers down (and getting the admission of error) restricts their freedom of movement. I don't know who wrote this, but it seems to describe the value of the incremental approach:
Hume sprinkled his gunpowder through the pages of the “Dialogues” and left the book primed so that its arguments would, with luck, ignite in his readers’ own minds. And he always offered a way out. In “The Natural History of Religion,” he undermined the idea that there are moral reasons to be religious, but made it sound as if it were still all right to believe in proofs of God’s existence. In an essay about miracles, he undermined the idea that it is ever rational to accept an apparent revelation from God, but made it sound as if it were still all right to have faith. And in the “Dialogues” he undermined proofs of God’s existence, but made it sound as if it were all right to believe on the basis of revelation. As the Cambridge philosopher Edward Craig has put it, Hume never tried to topple all the supporting pillars of religion at once.

Mike Elzinga · 19 November 2007

I think part of what intrigues me about the issue is that in some cases we laud people for dogged determination to a theory to see it to wide spread acceptance. And in others we are critical of scientists for sticking with a theory as it accumulates uncorrected problems. It strikes me that your probably talking about similar personality traits in both cases, and yet some are heroes and others villans (after a fashion anyway).
A lot of it has to do with the connections of the individuals with the wider scientific community, the personalities of the individuals, and the way in which the ideas are presented. Keeping in touch with the wider community of scientists is seen more as an act of good faith whereas skulking around in isolation and hinting paranoid suspicions of ones peers will turn most potential colleagues off. But one needs to be careful to distinguish between the normal rough-and-tumble of the scientific vetting process and the harsh criticism of quackery. Most scientists dont take blunt criticism personally. It's part of the process of checking all angles. The ID/Creationists want to be treated gently and with a respect that they haven’t earned. When they are critiqued by the scientific community, they whine to their religious base that they are being mistreated. When Behe and others associate with a crowd that is on record for its distortions of science, its use of demagoguery and debating tricks, and playing to a sectarian gallery with political ambitions, they pretty much discredit themselves right from the start. Many major scientific contributions have met with intense resistance, but the scientists promoting those ideas didn’t turn to a political constituency and try to pass laws to have their theories placed in high school science classes. Instead, they did what any good scientist does; get the evidence, even if it takes a lifetime. One might take Galileo as an example of someone who went to the “masses” by publishing in Italian instead of the official Latin used for scholarly work. However, he was dealing with a paranoid religious hierarchy that was battling a Protestant Reformation and fighting back by banning all appearances of heresy. And Galileo often used some of the same provocative language that others in his society used in promoting their ideas. It is interesting to read some of his writings because they would seem provocative even today.

twain · 19 November 2007

oh it makes me sad to see people picking on cryptozoologists....it all sounds like so much fun....like daydreaming

http://tshirtinsurgency.com/

Stuart Weinstein · 19 November 2007

Staton writes:

"It wasn’t that Lord Kelvin hedged his bets, it was that, according to his calculations, if Earth started out as a big ball of molten rock, that 30 to 50 million years would be how long it would take for it to cool down and become solid. Had he lived after the discovery of radioactivity, he would have realized that rock can stay molten for much longer periods of time, i.e. billions of years rather than millions of years, if it was constantly being irradiated."

The basic problem with Kelvin's model was that he assummed the Earth could only cool through conduction. Had he understood the physics of convection (later explained by Rayleigh) he might reached a different conclusion.

Inoculated Mind · 19 November 2007

Behe wrote anotheer response. Get a load of this:
Dr. Musgrave misunderstands my point. I did not say that Vpu acted as a nonspecific wad of chewing gum. Rather, my point is a general one, that, initially, when during the course of evolution a viral or bacterial protein is injected for the first time into a cell, it is encountering a new environment, one it hasn’t adapted to before, and which hasn’t adapted to it. In that case there are many “targets of opportunity” for the foreign protein. If by serendipity it sticks to some cellular protein to a certain degree, and that association interferes to a degree with the function of the cellular protein, then that will likely benefit the virus, and the association can be strengthened by mutations to the viral protein over time.
Oh yes, binding to any protein at random will do. Interfere with any protein and the virus will succeed. So wrong. Funny how it binds to specific proteins, and not others. Just like cellular proteins.
That’s why I put cellular protein-protein interactions in a different category from foreign protein-cellular protein interactions.
No, you hunted through the literature to pick out a few references that you could salvage to try to make it seem like you knew what you were talking about. If you meant to say all this about viral-cellular protein interactions in the first place, you wouldn't have compared it to a wad of chewing gum! I find it interesting that Behe decided to announce from the outset that he would be writing FIVE responses to Ian Musgrave. In the middle of writing them, Ian countered several of Behe's arguments in his responses - which didn't come up until after he started his "series" of responses. I wonder, what did he plan to argue in the other essays, but thought it was more important to try to save face against the onslaught? Finally, who want's to bet that Behe won't stop at five?
"This is part six of five responses..."

steve s · 19 November 2007

Finally, who want's to bet that Behe won't stop at five?
Horrible abuse of the apostrophe.

Frank J · 19 November 2007

His claim is that for any decent binding site to get started, you need three or more simultaneous mutations.

— Ian Musgrave
What does he even mean by "simultaneous"? IIRC, at the molecular level, reactions take milliseconds or less, so that even if he was right in that they had to occur in a single cell in a single generation, that's a lot of opportunity for 3 or more mutations. And just because it happens rarely if at all, there are no laws of chemistry (as opposed to statistical laws) that prevent it. But the point I keep making is that he probably knows that he is wrong, regardless of how he defines "simultaneous." That's because such a claim would present many wonderful opportunities for testing - opportunities which he avoids as consistently as he avoids answering critics' simple questions. Specifically, the test could examine how cellular environments might favor certain combinations of 3 or more mutations in a generation. Could there really be something Lamarckian going on every now and then? Maybe in the Cambrian? Meyer would love that last one.

Frank J · 19 November 2007

I shouldn't have to remind everyone that not one of the "6 of his 5 response" is posted here, where comments are not disabled. And where those who just read Behe to get their fix of feel-good sound bites would have to see the inconvenient answers - in context.

Torbjrn Larsson, OM · 19 November 2007

... when during the course of evolution a viral or bacterial protein is injected for the first time into a cell, it is encountering a new environment, one it hasn’t adapted to before, ...
I think Ian answered that one already, viruses adapt to hosts that are sufficiently like the old ones or they can't replicate. You know, I somehow get the feeling that Behe is assuming that viruses are created de novo instead of coevolving with their hosts as in the model he is supposed to analyze?! They are in a similar situation that the hosts cells, as the later need working cell machinery for duplication or sexuality. Just the naked genome doesn't cut it here. It's as if Behe has never heard of cell machinery or interlocking complexity before.
Add to that the constant that Einstein’s proposed to keep the universe stable.
Well, perhaps not admitted in the sense discussed here. Einstein never said so in public AFAIU, and it isn't certain that he said it in private:
Much later, when I was discussing cosmological problems with Einstein, he remarked that the introduction of the cosmological term was the biggest blunder of his life. -- George Gamow, My World Line, 1970 [1] ... [1] It is just as well that Einstein made this remark to Gamow, otherwise Gamow would have been severely tempted to make it up.
Gamow was an excellent storyteller, as anyone reading his Mr. Tompkins popular science books would know. And had Einstein said so and lived today he would have to admit another error, since the cosmological constant is alive and well, used as the effective description of dark energy in cosmological models. But indeed it looks like one mess of Einstein as described in the link above, as he implemented it partly destroying the beauty of his own theory. And if he had been actively aware of Olber's paradox and its solution, later more widely recognized, it is easy to think that this great user of simple arguments would have at least discussed the problem it poses.

Ian Musgrave · 19 November 2007

Inoculated Mind: Behe wrote another response. Get a load of this:
Dr. Musgrave misunderstands my point. I did not say that Vpu acted as a nonspecific wad of chewing gum. Rather, my point is a general one, that, initially, when during the course of evolution a viral or bacterial protein is injected for the first time into a cell, it is encountering a new environment, one it hasn’t adapted to before, and which hasn’t adapted to it. In that case there are many “targets of opportunity” for the foreign protein. If by serendipity it sticks to some cellular protein to a certain degree, and that association interferes to a degree with the function of the cellular protein, then that will likely benefit the virus, and the association can be strengthened by mutations to the viral protein over time.
Already dealt with in An Open Letter Part 7 (see main post for link) and comment 135672

Torbjrn Larsson, OM · 19 November 2007

... Hume never tried to topple all the supporting pillars of religion at once.
Ooh, finally a working example of framing. But one could debate the feasibility of out-sneaking apologists.

Stephen Wells · 19 November 2007

I still think that Behe really thinks that nothing you guys point out (best fisking ever, BTW) is actually _evolution_; all those biological changes in HIV were deliberately put there by demons. I wonder when he'll finally come out and say it.

hoary puccoon · 19 November 2007

Stanton-- I don't have a library available here, but I do recall reading the same thing you and GVL Geologist mention, that Lord Kelvin estimated what the temperature of the earth should be, without calculating the effect of radioactivity (which was quite unknown at the time.) I hadn't before read, as Stuart Weinstein said, that Kelvin only knew about cooling through conduction, not convection.

I'm pretty sure, that at some point Kelvin did hedge with the caveat that his calculations held unless some unknown energy source were discovered. I wish I could remember where I read about the young scientist who had to give a talk on the recalculated (much older) age of the earth with the great man himself in the audience. That's when, based on Kelvin's caveat, he was able to say something like, "As Lord Kelvin so presciently noted...."

JGB-- Glen Davidson and I went around (politely) about the Wegener-continental drift thing in the last post Nick Matzke made before he started grad school. A number of people jumped in, with lots of detail. It wasn't so much that everyone in the original continental drift debate was wrong, as that everyone was partly right. Wegener correctly analysed the fossil data and concluded that the continents must have moved, but the mechanism he hypothesized to explain the movement was geologically impossible, as the geologists correctly pointed out. (Their basic alternative hypothesis, that species moved around on land bridges or drifting on rafts of vegetation, is, in some cases, still accepted, too.) It was only after oceanographers (literally) dredged up new data, and discovered ocean floor spreading, that the conflict could be resolved.

William E Emba · 19 November 2007

Lord Kelvin hedged his bets when he claimed the earth couldn’t be more than some [tens of millions] of years old, and added something like “unless a completely new form of energy is discovered.” So when atomic energy was discovered, nobody had to say the great man was wrong. They called him “prescient!”

— hoary puccoon
I don't think Lord Kelvin mentioned the loophole explicitly, although it was obviously part of his calculations. But he was quite insistent that Darwin's time scale was impossible, so he favored a saltationist version of evolution. He lived long enough after the discovery of radioactivity for people to realize his calculations were irrelevant. Lord Rutherford was probably the first to see this. He tells of giving a lecture as a young man, where he first presented a revised age of the earth compatible with pure Darwinian evolution, and to his consternation, the elderly Lord Kelvin was in the audience. So he felt better when Lord Kelvin fell asleep right away. And then Lord Kelvin woke up in time for the good part, and the young Lord Rutherford was inspired to repackage Lord Kelvin's calculations as a prescient prediction of the now discovered radioactivity, leaving Lord Kelvin beaming. The humorous irony is that saltationism remained an evolutionary bugaboo for decades ("hopeful monsters") afterwards before it was finally bypassed as pointless nonsense. The only advocates of saltationism today seem to be ex-scientists like Behe. Just how dumb is a modern day saltationist? Every so often a discrepancy in gravitational calculations is found. In the early 1800s, Uranus' orbit proved impossible to calculate using Newtonian gravity. Eventually, the new planet Neptune was predicted and it explained most of the error. It wasn't until the Voyager 2 flyby that an accurate mass for Neptune was determined and Uranus' orbit was indeed calculable accurately from first principles. More revolutionary was the precession of Mercury's perihelion, which ultimately was explained by Einstein's general theory of relativity, a remarkable revision of Newtonian gravity. In modern days, we have numerous discrepancies that keep the theorists and observers busy. Cosmological anomalies have given birth to notions like dark matter, dark energy on the one hand, or modified Newtonian theories on the other. The Pioneer anomaly doesn't even have a standard favorite explanation---it's hoped that the New Horizons spacecraft will resolve the questions. And you know what? There's never been an astronomer or physicist who has looked at any of these questions and gone back to Sir Isaac Newton himself and revived the great man's angels pushing planets correction to the laws of gravitation. "Intelligent Pushing" is laughably stupid. And you know what, so are Behe and Dembski.

Inoculated Mind · 19 November 2007

Horrible abuse of the apostrophe.
Horrible use of a fragment. (thanks for the grammar correction on a rapid late-night comment...) I'm still amazed at how detailed Behe's avoidance of admitting mis-statements is.

Paul Burnett · 19 November 2007

William E Emba noted: "The only advocates of saltationism today seem to be ex-scientists like Behe."

That's a good example of framing. From now on, we should all refer to Behe as an "ex-scientist." I'm sure his fellow biologists at Lehigh University would agree. (See http://www.lehigh.edu/~inbios/news/evolution.htm )

Frank J · 19 November 2007

The only advocates of saltationism today seem to be ex-scientists like Behe.

— William E. Emba
And they are shrewd enough not to mention it by name (or anything close). Same for those who deny common descent, and not daring to admit that they are proposing "a whole lot of abiogenesis."

Dave Cerutti · 19 November 2007

It seems Mr. Behe's response is standard procedure for creationists when entering a truly scientific debate. Behe has said one thing, you've responded "false, counterexample..." and he then proceeds to take you to task, making you go to great lengths to establish your position. Always, the burden of proof is kept on evolution, because it is a positive statement of the way things work.

The effect is that, once Mr. Behe's demands are satisfied, the issue is so specific that it is necessarily very particular, and thus Mr. Behe can just give it a nod, as he did, and make the most minimal of concessions.

Expect another whopping, blanket statement about the impossibility of evolution erre long.

Stanton · 19 November 2007

Dave Cerutti: It seems Mr. Behe's response is standard procedure for creationists when entering a truly scientific debate. Behe has said one thing, you've responded "false, counterexample..." and he then proceeds to take you to task, making you go to great lengths to establish your position. Always, the burden of proof is kept on evolution, because it is a positive statement of the way things work. The effect is that, once Mr. Behe's demands are satisfied, the issue is so specific that it is necessarily very particular, and thus Mr. Behe can just give it a nod, as he did, and make the most minimal of concessions. Expect another whopping, blanket statement about the impossibility of evolution erre long.
This is, sadly, a very convenient tactic that ID proponents/Creationists use to deflect attention from the small, but oh so terribly fatal fact that ID/Creationism has absolutely no scientific applications whatsoever.

Mike Elzinga · 19 November 2007

Dave Cerutti: It seems Mr. Behe's response is standard procedure for creationists when entering a truly scientific debate. Behe has said one thing, you've responded "false, counterexample..." and he then proceeds to take you to task, making you go to great lengths to establish your position. Always, the burden of proof is kept on evolution, because it is a positive statement of the way things work. The effect is that, once Mr. Behe's demands are satisfied, the issue is so specific that it is necessarily very particular, and thus Mr. Behe can just give it a nod, as he did, and make the most minimal of concessions. Expect another whopping, blanket statement about the impossibility of evolution erre long.
Indeed their tactics are sleazy and well-planned. I have watched these characters since the mid 1970s. I made reference to the standard shtick on a previous thread (with corrections to my egregious spelling errors in the very next comment). As far as I can tell, the tactics are still basically the same, with refinments being added as they adapt to being discovered.

Reynold Hall · 19 November 2007

These letters will be a good extra bit of information, along with the Dover transcripts, to use against those guys. Escpecially when they're bragging about how good Behe is when it comes to AIDS research!

hoary puccoon · 19 November 2007

JGB wrote:

"...in some cases we laud people for dogged determination to a theory to see it to wide spread acceptance. And in others we are critical of scientists for sticking with a theory as it accumulates uncorrected problems. It strikes me that your probably talking about similar personality traits in both cases, and yet some are heroes and others villans (after a fashion anyway)."

That's an interesting point. Again, I'd say read Francis Crick's "What Mad Pursuit." Crick says something like, don't just tinker with your theory when problems come up. Look for a crucial test that will make it or break it. If it breaks, move on. Of course, Crick was advising honest scientists, not con artists like the creationists and IDers. Mike Elzinga's post, which he refers to above, describes the tactics I've seen from them pretty exactly.

Whether scientists are trying to come up with that crucial test is one gauge of whether they're "heroes or villians." Louis Agassiz, possibly the last creationist who was a legitimate scientist, went to Brazil late in his life looking for evidence of glaciation-- one could say, a crucial test of his theory. (It failed. Even in the ice ages, Brazil wasn't covered with ice.)

To be fair to Agassiz and the other catastrophists, they were correct in thinking the fossil record showed evidence of catastrophic extinctions (which Lyell, Darwin and other uniformitarians tended to deny or downplay.) They just weren't right that ALL life was extinguished and had to be restarted again and again.

That 'crucial test' criterion is one sign of serious science. Why isn't Behe in the lab, proving that his 'simultaneous mutations' are all lethal if they appear individually, and therefore must be simultaneous? Why isn't he looking at malaria where not much chloroquinine has been used and seeing if his favored mutations appear naturally in the population? Why did he care about Abbie Smith's tone in addressing him, instead of her relevant data?

Oh, yeah. I forgot-- Behe is an ex-scientist. Well, never mind.

Mike Elzinga · 19 November 2007

Another characteristic that ID/Creationism has in common with other pseudo-sciences is the invention and proliferation of scientific-sounding words. These are words that have fuzzy meanings (or no meanings at all), and they are foisted onto a naive following to give the pseudo-science a patina of sophistication.

Leaders of these movements attempt to force the discussions of their claims into the language they have invented. Thus, any critic of these ideas must go through a protracted process of trying to extract the meanings of these invented words in an attempt to get any comprehensible response from the leaders and followers of these movements. During this process, the cult leaders generate more fuzzy words to explain the original fuzzy words.

Typical retorts to skeptical probing imply that the concepts are so advanced that the inertia of the science community blocks the airing of these “profound” ideas. And, of course, the originators of these words manage to drop a few hints that suggest they are among the top scientists of history.

These words also help the followers of these movements feel they have “special insights” that are denied ordinary people and jealous scientists; giving the movement social cohesiveness and a set of shibboleths to identify “outsiders”.

So words like Scientific Creationism, Complex Specified Information, Irreducible Complexity, Intelligent Design, etc. all belong to the pantheon of other famous words such as Orgone Energy, Pyramid Power, Aura, Telic Field, Vibrations; the list goes on and on.

Ravilyn Sanders · 19 November 2007

Mike Elzinga: Another characteristic that ID/Creationism has in common with other pseudo-sciences is the invention and proliferation of scientific-sounding words. [snip] So words like Scientific Creationism, Complex Specified Information, Irreducible Complexity, Intelligent Design, etc. [snip]
Very true. I think we should compile a glossary of these terms and demystify them. The most recent one I came across was "biotic reality", that appears to be just a dressed up word for viable critter. Some guy was arguing Dawkins was ignoring "biotic reality" in explaining many small steps leading to an impossibly tall cliff. Anyone who actually read Climbing the Mount Improbable knows to what lengths he went to describe that every step should be a viable creature, totally preoccupied with surviving and reproducing etc. A simple blanket statement like that allows them close their ears and mind.

Mike Elzinga · 19 November 2007

A simple blanket statement like that allows them close their ears and mind.
Probably another example of an avoidance response. It reminds me of the multiple times I have seen some of the fundamentalists I have known glaze over in a technical conversation about evolution. They initiate a challenge conversation about some technical matter regarding evolution but as soon as you respond with a bunch of technical terms indicating some understanding of the matter, their eyes go blank, and their face goes slack, and then they start spouting gibberish. I think these were some of the rank-and-file who tried to memorize their debating lines and discovered it didn’t work around somebody who knew something. Your example appears to be of someone who has advanced to the next stage by trying to give the appearance of having knowledge “beyond” the current scientific picture. That takes a bit more chutzpa. And it launches you into definitions and epistemology and all the other “how-do-you-know” arguments. Blech!

Alan R. · 19 November 2007

An interesting idea for Panda's Thumb would be a dictionary of ID terms. I would allow the person who created the term to provide any required corrections or refinements to the dictionary. That way there could be no complaint about its accuracy.

Paul Burnett · 19 November 2007

Ravilyn Sanders said: "I think we should compile a glossary of these terms and demystify them."

Good idea. Let's also review the infamous "Seven Warning Signs of Bogus Science," some of which certainly pertain to cdesign proponentsists:

1. The discoverer pitches the claim directly to the media.

2. The discoverer says that a powerful establishment is trying to suppress his or her work.

3. The scientific effect involved is always at the very limit of detection.

4. Evidence for a discovery is anecdotal.

5. The discoverer says a belief is credible because it has endured for centuries.

6. The discoverer has worked in isolation.

7. The discoverer must propose new laws of nature to explain an observation.

(http://chronicle.com/free/v49/i21/21b02001.htm)

Mike Elzinga · 19 November 2007

“Seven Warning Signs of Bogus Science,”

Paul: Great idea! I recognize that list from somewhere. Ah, yes, Robert Park in his Voodoo Science, The Road from Foolishness to Fraud, and that Chronical.com article is by him. I seem to recall that Martin Gardner had a list of these in one of his writings. Do any others here know of other works where one can glean a comprehensive list. Maybe we could get them up here and distill them down. The list Paul gave is a pretty good one.

rimpal · 19 November 2007

Time to cast off the tedium. The Wizards of Washington; the Sages of Seattle have spoken. Design of Life is just out. Time for some "shooting fish in a barrel".

Mike Elzinga · 19 November 2007

rimpal: Time to cast off the tedium. The Wizards of Washington; the Sages of Seattle have spoken. Design of Life is just out. Time for some "shooting fish in a barrel".
A postmortem might be a better characterization, however, this thing may not be dead. Better to see how we got here and how this thing may evolve, because evolve it will. (BTW, Didn't those Myth Buster guys bust the shooting-fish-in-a-barrel myth? I didn't get to see the end of it, but what I saw was quite funny.)

Paul Burnett · 19 November 2007

Rimpal wrote: "Design of Life is just out."

Announcement at http://www.evolutionnews.org/2007/11/design_of_life.html

It starts by mentioning "...a small non-profit in Texas, The Foundation for Thought and Ethics (FTE)" It's worth going back and reading the Dover transcripts to see how the CEO of FTE repeatedly perjured himself, denying FTE is a Christian organizaion.

Here's some gems:

The new Pandas "recount(s) many of the peer-reviewed scientific papers, scientific books, and laboratory studies completed by ID theorists."

The new Pandas "also explain(s) why Darwinists have thus far failed to explain the evolution of the bacterial flagellum."

"If Darwinists reacted strongly in fear over the scientific arguments in Pandas, they will go supernova after reading The Design of Life."

Enjoy! (I wonder how many times the new Pandas mentions cdesign proponentsists?

Mike Elzinga · 20 November 2007

Fast forward to 2008, and Pandas’ successor, The Design of Life, written by leading ID theorists William Dembski and Jonathan Wells, brings readers up to speed on the numerous advancements of ID over the past 20 years. Design of Life is more than twice as long as Pandas, recounting many of the peer-reviewed scientific papers, scientific books, and laboratory studies completed by ID theorists. It offers an excellent up-to-date account of ID for any reader.

So where did all this research and development take place? Dr. Frankenstein's basement? Who did the peer-reviewing? I haven't seen any comments in any journals I know about. You would think it would be mentioned somewhere. Oh, I forgot; we have a surprise new product and that's not the way marketing works. It's alive! It's alive!

Ian Musgrave · 20 November 2007

Paul Burnett: Rimpal wrote: "Design of Life is just out." ..... The new Pandas "recount(s) many of the peer-reviewed scientific papers, scientific books, and laboratory studies completed by ID theorists."
[Marvin the Paranoid Android] I've seen it, it's rubbish [/Marvin the Paranoid Android] It's the same old biologically incompetent mess that we have grown to know and ... well, know. With pretty pictures as well. But the lab studies, as usual, they have latched onto stuff that has no relevance to or support for ID. Watch PT for a post on just this topic really soon.

Frank J · 20 November 2007

Now I'm really confused. I though "Explore Evolution" was their new "design-free" replacement for "Pandas." The excerpt I read in it was classic "replacement scam": misrepresent evolution, and don't even hint what happens instead. Is it that EE is for public high schools and DOL is for college, where they are freer to discuss religious concepts in science class?

Frank J · 20 November 2007

My comments follow Casey Luskin’s quotes.

Why have Darwinists gone to such lengths to attack Pandas?

The catch-22 of pseudoscience; ignore it, and its defenders claim that you take it seriously; refute it in detail and its defenders claim that you take it seriously. At least the latter is informative to those wanting to learn, and not just seek out feel-good sound bites. BTW, did you notice that Luskin omitted the links to the many reviews of “Pandas,” unlike most critics of ID pseudoscience, who are more than happy to provide links. Oh yes, and note the now-obligatory use of the word "Darwinists".

“All readers will appreciate Design of Life’s devastating critique of chemical origin of life hypotheses and hypotheses about universal common descent. The book provides piles of examples where the molecular data has conflicted with expectations of universal common ancestry and refutes the Darwinist icon that pseudogenes demonstrate that humans share common ancestors with other mammals.”

There goes that “universal” qualifier for common descent again. Any bets that they won’t critique Carl Woese, who technically denies “universal” common descent, but not that “humans share common ancestors with other mammals?” And note also that even if they were right that pseudogenes do not necessarily support common ancestry of humans and “other mammals,” that does not mean that the common ancestry would be falsified, let alone that independent abiogenesis of different lineages (the formal conceptual alternative) would be supported. If Luskin’s words are any indication, the book will be a masterpiece of cherry picking, quote mining and creative language. I hope they find a slicker weasel word than “common design,” though. That one’s getting a little stale.

hoary puccoon · 20 November 2007

Casey Luskin:

"...Design of Life’s devastating critique of chemical origin of life hypotheses...."

Oh, good. Let's confuse evolution and abiogenesis again. That's SUCH a novel approach.

Frank J · 20 November 2007

Note also the phrase: “chemical origin of life hypotheses.”

What ID activists won’t tell you is that every hypothesis of how life originated is challenged by some real scientists, and every one will of those scientists will admit those disagreements, and that there is not yet a theory of how life originated. But evolution doesn’t claim to have one, so ID can’t have it both ways. Either ID claims to be only an alternative to evolution, in which case any discussion of abiogenesis is irrelevant, or it claims to have a better hypothesis of abiogenesis. But ID provides not even a hint of its own hypotheses, either for how life originated, how subsequent species originated, or how their beloved IC systems originated.

What ID activists know that they can’t dispute is the fact that life had to originate from non-life at least once by definition, and that the best evidence indicates that it happened once or at most a few times, 3-4 billion years ago. Michael Behe, the DI’s closest thing to a real scientist, has in fact admitted that rather explicitly, and continuously for more than an decade. And despite all the suggestions by other ID activists that “Darwinists” might be wrong about it, that have not once challenged one of their own on it. Why is that?

Note in particular the clever use of the “chemical” qualifier. That serves two rhetorical purposes. One is to subtly placate the audiences who truly believe that life came from a vacuum as opposed to pre-existing matter. The other is to exploit the public’s distrust of the word “chemical.” Don’t even get me on that tangent; when it comes to “chemical,” 90+% of the people think like creationists.

Ravilyn Sanders · 20 November 2007

hoary puccoon: Oh, good. Let's confuse evolution and abiogenesis again. That's SUCH a novel approach.
Hoary Puccoon, The way the creationist mind works, "I don't believe A, nor do I believe in B, so it proves A is identical to B". In their mind there is really no difference between the theories about the evolution of life, the origin of life or the origin of universe. It is all scientific mumbo jumbo to them. The creationists are like the Cargo cults that sprang up after the WW-II in New Guinea and other Pacific Islands. "OK I have constructed series of bamboo towers. Strung up jungle vines between them. Cleared a long thin rectangle and leveled it and lit oil lamps ceremoniously. I cover my ears coconut shells. I sit on a desk and chant the magical incantations, 'Flight 343 come in, Flight 343. This is Henderson Air Force Base' over and over again. Huge silver ships carrying valuable cargo will appear over the horizon soon". The creationists understand science just as much as the cargo cults understood military aviation.

trrll · 20 November 2007

What ID activists won’t tell you is that every hypothesis of how life originated is challenged by some real scientists, and every one will of those scientists will admit those disagreements, and that there is not yet a theory of how life originated.
Imagine if chemical origin of life hypotheses were expressed with the same degree of specificity as ID: "Life originated from simple chemicals (we won't say which) at some time (we won't say when) as a result of spontaneous chemical reactions (we won't say how)." Critique that! But of course, that is not how science works. Scientists strive to make their hypotheses as specific as possible so the at they can be critiqued, because it is out of such critiques than new understanding and better hypotheses arise (unfortunately, the "critiques" of OOL theory offered by ID/creationists are so ignorant and fallacious as to be scientifically worthless--far better critiques have been offered by the scientists pursuing the various competing hypotheses). ID, in contrast, strives to make its hypothesis as vague as possible, to avoid any possible observational or experimental test. It is this, fundamentally, that identifies ID as religion rather than science.

MartinM · 20 November 2007

“Life originated from simple chemicals (we won’t say which) at some time (we won’t say when) as a result of spontaneous chemical reactions (we won’t say how).”
And, of course, the what, when and how may or may not be knowable.

William E Emba · 20 November 2007

Add to that the constant that Einstein proposed to keep the universe stable.

— Torbjrn Larsson, OM
Well, perhaps not admitted in the sense discussed here. Einstein never said so in public AFAIU, and it isn’t certain that he said it in private [...]

Einstein dropped the cosmological constant from his later accounts of relativity. I'd call that a louder admission than any putative "biggest mistake in my life" quotation.

William E Emba · 20 November 2007

Add to that the constant that Einstein proposed to keep the universe stable.

— Torbjrn Larsson, OM
Well, perhaps not admitted in the sense discussed here. Einstein never said so in public AFAIU, and it isn’t certain that he said it in private [...]

Einstein dropped the cosmological constant from his later accounts of relativity. I'd call that a louder admission than any putative "biggest mistake in my life" quotation.

Mr_Christopher · 20 November 2007

Hats off to Ian Muskgrave's "open letters" series. You're a great asset to PT and science in general. And hat's off to Behe for responding to at least some of the objections.

I hope we see some "open letters" addressed to Dembski and Wells soon regarding the latest version of Pandas.

Mr_Christopher · 20 November 2007

Oops, I'll take that "k" back. No sense in wasting a perfectly good "k" (Musgrave/Muskgrave).

Frank J · 20 November 2007

ID, in contrast, strives to make its hypothesis as vague as possible, to avoid any possible observational or experimental test. It is this, fundamentally, that identifies ID as religion rather than science.

— trrll
Ironically that makes ID even more like religion than classic creationism. At least the latter spells out some testable hypotheses regarding the whats and whens, and occasionally engages in healthy YEC-OEC debating. The problem is that, even overlooking how specific creationist hypotheses failed the tests, by the 1980s the mutually contradictory creationist positions were hopelessly deadlocked. That forced at least one "species" of creationism to adopt a "don't ask, don't tell" approach - even before "Edwards v. Aguillard" forced the hasty relabeling of it as ID.

CJO · 20 November 2007

Hats off to Ian Musgrave’s “open letters” series. You’re a great asset to PT and science in general. And hat’s off to Behe for responding to at least some of the objections.

This is excellent work, and appreciated. But. I can't help thinking that the exchange plays into Behe's hands to a degree. It's an example of what Frank J called "the Catch-22 of pseudoscience," above. Sure, Behe finally capitulates on the factual errors, after a lot of noncommital and irrelevant mumbling. And we understand that it's not a minor point, that the objection in this case really does go to the heart of Behe's claims in EoE. But the faithful, by and large unable to follow the argument or understand the import of the errors, just see scientists digging further and further into one specific point until Behe does finally admit error, begrudgingly and without conceding his thesis. Why Behe still looks good to some is that 1) They don't see the import of the concession and so can write it off as an inevitable minor error --one that took a great deal of persistance on the part of ERV and Ian (among others) to expose-- while continuing to believe that his thesis is viable, and 2) Their hero looks courageous by finally admitting to error. The take-away for the already convinced is: The mean ol' Darwinistas picked some minor point and hammered it into the ground because they couldn't refute the larger argument at a fifth-grade reading level and look: our boy Mike is still standing! 'Tis but a flesh wound!

Glen Davidson · 20 November 2007

The take-away for the already convinced is: The mean ol’ Darwinistas picked some minor point and hammered it into the ground because they couldn’t refute the larger argument at a fifth-grade reading level and look: our boy Mike is still standing! ‘Tis but a flesh wound!

That, and Behe hasn't in the slightest agreed to use the scientific method. All he and his cohorts have to do, under their "standards", is use some other criticism of "Darwinism", and supposedly their claims are supported. No need for them to, you know, come up with any evidence for their claims at all. It's sort of sad, actually, to fight them at all on their own grounds, even when they're wrong about something that substantial. It suggests to the "faithful" that, after all, Behe is doing science, it's just that he was wrong on 'this one point' (at these times they become forgiving, for once). So they can just try again using the same pseudoscientific false dilemmas and assertions that (in essence) they have no burden to produce any evidence that design has occurred in life. Not that it's a bad thing to show their incompetence even within their own incompetent view of science--indeed it is a good thing. But we can never let up on the fact that even had Behe been right on the details of HIV, that would have done absolutely nothing to bolster ID's claims to be science. Glen D http://tinyurl.com/2kxyc7

Mike Elzinga · 20 November 2007

The take-away for the already convinced is: The mean ol’ Darwinistas picked some minor point and hammered it into the ground because they couldn’t refute the larger argument at a fifth-grade reading level and look: our boy Mike is still standing! ‘Tis but a flesh wound!
Yeah, we have seen this part of the shtick before. The reinforcement for this is currently being promulgated with the slick movies and CDs showing many of the beautiful examples of life on this planet. The message: “How can all this beauty be the result of blind, random forces? It must have been designed.” And, of course, the hint is dropped, somewhere in all this, that those mean ol’ Darwinists have dark, evil minds that are unable to see and appreciate the beauty (and design) around them, so they want to turn everyone else into the ugly beasts that they are. Pretty, shiny things are designed and appreciated by good people. Evil people like ugly, grotesquely shaped things that are black and produced by chaos. So the emotional manipulation reaches down to the childish fears in their audience. I've seen it done already on one of the religion channels (I think the Coral Ridge Hour).

CJO · 20 November 2007

"evil minds that are unable to see and appreciate the beauty" in the exquisite design of HIV and malaria. Such Philistines we are!

Henry J · 20 November 2007

The message: “How can all this beauty be the result of blind, random forces? It must have been designed.”

And never mind that our appreciation of beauty in nature arose so as to appreciate what was already there. If things looked different than they do, we'd have evolved to appreciate that, instead. Henry

trrll · 20 November 2007

Ironically that makes ID even more like religion than classic creationism. At least the latter spells out some testable hypotheses regarding the whats and whens, and occasionally engages in healthy YEC-OEC debating. The problem is that, even overlooking how specific creationist hypotheses failed the tests, by the 1980s the mutually contradictory creationist positions were hopelessly deadlocked. That forced at least one “species” of creationism to adopt a “don’t ask, don’t tell” approach - even before “Edwards v. Aguillard” forced the hasty relabeling of it as ID.
Yes, I think that there was a time when creationism was science, or at least "natural philosophy." The creationists of Darwin's day debated such issues as whether a single creation event was sufficient, or whether some form of non-Biblical creationism (e.g. multiple creations) was required for consistency with the evidence. The problem for modern creationists is that all genuinely scientific forms of creationism were well on their way to being rejected based upon experimental and observational data even before Darwin came along to provide a clear explanation for the evolution that was so obvious from the fossil record.

hoary puccoon · 20 November 2007

Ravilyn Sanders responded to me, about evolution vs. abiogenesis--

"The way the creationist mind works, “I don’t believe A, nor do I believe in B, so it proves A is identical to B”. In their mind there is really no difference between the theories about the evolution of life, the origin of life or the origin of universe. It is all scientific mumbo jumbo to them."

That's undoubtedly true for the creationist rank-and-file, Ravilyn, but for Dembski, Wells, and Luskin, I don't buy it. I think they know perfectly well that when they conflate evolution and abiogenesis they are twisting words and misleading their audience. In my darkest moments, I even suspect they take a sadistic pleasure in seeing how many lies they can get their trusting supporters to swallow.

Ian Musgrave · 20 November 2007

Mr Christopher wrote in comment 135750
I hope we see some "open letters" addressed to Dembski and Wells soon regarding the latest version of Pandas.
No, they are not scientists and educators who have beaten up on any graduate students, so no open letters to them. They will get what’s coming to them though. I’m working on a post at the moment. However, such detailed posts take a great deal of my free time, which I could be using to spend with my family, or doing astronomy. Refuting page after page of nonsense gets bone-wearying after a while. But Dembski and the DI are coming in for a little bit of trouble , which may dwarf my small critiques.

Ian Musgrave · 20 November 2007

Mike Elzinga wrote in comment 135770
Pretty, shiny things are designed and appreciated by good people. Evil people like ugly, grotesquely shaped things that are black and produced by chaos.
Now, to be fair to Dr. Behe, he addresses this issue head on and concludes that the “designer” does design things that are horrible as well (see especially pages 238-239).
Denying design because it causes terrible pain is a failure of nerve, a failure to look the universe fully in the face.
Dr. Behe does acknowledge that “all things squat and nasty” are the work of the “designer” and departs from many of his ID compatriots in this stance, and we should not lump him in with them.

Mike Elzinga · 20 November 2007

Now, to be fair to Dr. Behe, he addresses this issue head on and concludes that the “designer” does design things that are horrible as well (see especially pages 238-239).

Understood, Ian. And thanks. But I was commenting on what some of the rank-and-file churches are still doing on the religion channels. I suspect they have their own agenda, but they draw from the ID literature and the credits acknowledge the DI's prepared materials.

Torbjörn Larsson, OM · 21 November 2007

Einstein dropped the cosmological constant from his later accounts of relativity. I’d call that a louder admission than any putative “biggest mistake in my life” quotation.
Agreed, William. And thanks for filling in my sloppy omission.

Glenn Shrom · 16 December 2008

I don't think Behe would ever say that the immune system could not have evolved. Behe's approach seems to say that the evolution of the immune system must have been the result of intelligent design at at least one point along the evolutionary path, perhaps at the very beginning.