Smarch of the Fossil Penguins

Posted 2 May 2011 by

My research doesn't have an easy outreach component. There is only so much you can do to get K-12 students interested in the bioinformatics of indels. My colleague Dan Ksepka has a much better time getting the public interested in his research. Of course, he works on the giant fossil penguins of Peru (http://fossilpenguins.wordpress.com/). He recently gave a talk on penguin evolution to open NC State's seminar series for research professionals. Luckily it has been archived online. So grab the munchkins, sit them in front of the monitor, and let them marvel the awesomeness of penguins the size of Danny Devito. Fossil Penguins: A 60 Million Year Journey From Wings to Flippers

159 Comments

Jeremy Mohn · 2 May 2011

This was great, Reed. Thanks for sharing!

Henry J · 2 May 2011

But do they carry umbrellas?

Robert Byers · 3 May 2011

YEC here.
The title implies it took 60 million years to go from wing to flipper.
Laying aside dates. the fossil penguins had arrived long before the 60 million by their datings.
A minor point.
Creationism agrees and welcomes that these were flying birds first. its welcome they were more healthy, that is diversity including hugh sizes, in the past with only remnants alive today.
lHowever the idea of in betweens between winging it and flipping it needs evidence.
I say its impossible.
In fact it was instant change within actual lives of the first birds or their kids that led to a swimming life and not a flying one. in fact atrophied wings is a common thing in the fossil record in the islands of the pacific. Its simply the extreme area of the Antarctic that allows some of the bigger ones and in large numbers to survive. A common thing as with mush oxen or Llamas. Otherwise extinction rules the earth.
I see penguins as a post flood adaptation of some bird. It changed instantly and ever since has been the same except for losing diversity.
Their cute.

Dale Husband · 3 May 2011

Robert Byers said: YEC here. The title implies it took 60 million years to go from wing to flipper. Laying aside dates. the fossil penguins had arrived long before the 60 million by their datings. A minor point. Creationism agrees and welcomes that these were flying birds first. its welcome they were more healthy, that is diversity including hugh sizes, in the past with only remnants alive today. lHowever the idea of in betweens between winging it and flipping it needs evidence. I say its impossible. In fact it was instant change within actual lives of the first birds or their kids that led to a swimming life and not a flying one. in fact atrophied wings is a common thing in the fossil record in the islands of the pacific. Its simply the extreme area of the Antarctic that allows some of the bigger ones and in large numbers to survive. A common thing as with mush oxen or Llamas. Otherwise extinction rules the earth. I see penguins as a post flood adaptation of some bird. It changed instantly and ever since has been the same except for losing diversity. Their cute.
Once more, Byers makes a statement that makes him look idiotic. There is absolutely nothing there that is supported by any evidence, let alone makes even a bit of sense.

Wayne Robinson · 3 May 2011

Robert Byers isn't just idiotic, he's also illiterate. Could someone possibly remind him that Peru isn't a Pacific island. It's actually a region (actually currently a country) on the South American mainland. 'Their cute' what? ...

erica h-g · 3 May 2011

Robert Byers said: However the idea of in betweens between winging it and flipping it needs evidence. I say its impossible.
I wonder if this fellow watched the presentation, or is simply riffing on the title. The speaker talks in detail about the transition from aerial to underwater flight, with lots of examples of living and extinct birds that are capable of both. More on topic, I noticed that the speaker uses the word "penguin" to refer not only to the body plan and lifestyle of the birds we all know and love, but also to the evolutionary lineage that includes volant birds. Now I am curious about what features might clue us in to recognizing a flighted penguin in the fossil record!

Lynn Wilhelm · 3 May 2011

Thanks for posting this, Reed. Yeah for NCSU researchers!

(NCSU grad, here.)

DS · 3 May 2011

Yea, penguins are obviously the result of the fall. They fell off a rock and into the ocean and they instantly started to swim, but they couldn't possibly have evolved in millions of years. I think they're downfall was all of the dancing. You know what that leads to. We got pictures of em doin it on TV, so who could argue? And there ain't no mediates neither.

Just another sample of creationist doin researches that disprovens evilution don't ya knows.

We love you Robert. Keep up the good work.

Science Avenger · 3 May 2011

Robert Byers said: I say its impossible.
You say that like it matters.

DS · 3 May 2011

Robert,

You should look at the presentation again. Apparently there were almost fifty different species of intermediates. Now how could you have missed that?

Thanks to Reed for the great link.

mrg · 3 May 2011

DS said: Now how could you have missed that?
I think that's a 24:7:365 habit of his.

John Kwok · 3 May 2011

Thanks for sharing this Reed. Dan has done some admirable work in public outreach regarding his paleobiological research. He spoke to the New York Paleontological Society back in 2005 and 2006 while he was in the midst of completing his Ph. D. research at Columbia (though based at the American Museum of Natural History, where he gave other talks there, aside from the two he gave to the New York Paleontological Society, which meets at the museum.).

KP · 3 May 2011

Robert Byers said: However the idea of in betweens between winging it and flipping it needs evidence. I say its impossible.
Impossible like the Phalacrocoracidae?

Kevin B · 3 May 2011

Science Avenger said:
Robert Byers said: I say its impossible.
You say that like it matters.
He's probably trying to accommodate the transitional form that carries an umbrella and resembles Burgess Meredith.

Karen S. · 3 May 2011

A common thing as with mush oxen
Is that a cross between a cow and a husky?

mrg · 3 May 2011

Karen S. said: Is that a cross between a cow and a husky?
No, that's a malamoo.

Stanton · 3 May 2011

mrg said:
Karen S. said: Is that a cross between a cow and a husky?
No, that's a malamoo.
Are you sure you're not thinking of a Spitzenstein?

Stanton · 3 May 2011

Robert Byers said: moronic babbling snipped I see penguins as a post flood adaptation of some bird. It changed instantly and ever since has been the same except for losing diversity. Their cute.
In other words, you're saying that, because you don't want to learn about science, God magically poofed penguins into existence, using magic, after the Flood, leaving no evidence whatsoever. So, why do we need to believe that your half-assed bellybutton contemplation is more scientific than actual science, and why are we supposed to assume that your babblings are supposed to supercede actual fossil evidence?

Walter · 3 May 2011

What genius at NCSU had the idea to use Silverlight for multimedia content? :((

Karen S. · 3 May 2011

Reed,

That was a fascinating video. Thanks so much for posting it.

cotton nero · 3 May 2011

The cherry on top of that steaming pile of turds (to mix metaphors) was the use of 'their' for 'they're'.

Klaus Hellnick · 3 May 2011

KP said:
Robert Byers said: However the idea of in betweens between winging it and flipping it needs evidence. I say its impossible.
Impossible like the Phalacrocoracidae?
KP, I think you mean Fratercula. Puffins use their wings to swim; cormorants use their feet.

Wayne Robinson · 3 May 2011

Walter said: What genius at NCSU had the idea to use Silverlight for multimedia content? :((
Probably someone in IT who only understands Windows. I can't watch the video because I only have Apple.

mrg · 3 May 2011

Stanton said: Are you sure you're not thinking of a Spitzenstein?
That sounds like the product of a lab in a Transylvanian castle. "IT'S ALIVE! IT'S ALIVE!"

BobbyEarle · 3 May 2011

Robert Byers said: I say its impossible.
Well, I'm convinced.

John Harshman · 3 May 2011

KP said:
Robert Byers said: However the idea of in betweens between winging it and flipping it needs evidence. I say its impossible.
Impossible like the Phalacrocoracidae?
Wrong family. Those are foot-propelled divers. Substitute Alcidae or Hydrobatidae and you'll have better luck.

NoNick · 3 May 2011

BobbyEarle said:
Robert Byers said: I say its impossible.
Well, I'm convinced.
Me too. I'm packin' it in and going out for a bicycle ride.

jj23 · 3 May 2011

http://www.evolutionnews.org/2011/05/president_obama_is_said_to046271.html

let's get this posted and start shredding klinghoffer's silly arguements...

John Harshman · 3 May 2011

jj23 said: http://www.evolutionnews.org/2011/05/president_obama_is_said_to046271.html let's get this posted and start shredding klinghoffer's silly arguements...
What arguments? I didn't see any in the article you linked to. Just assertio
jj23 said: http://www.evolutionnews.org/2011/05/president_obama_is_said_to046271.html let's get this posted and start shredding klinghoffer's silly arguements...
What arguments? I didn't see any in the article you linked to, not even bad ones. There were a few assertions. Is that what you meant?

Stanton · 3 May 2011

mrg said:
Stanton said: Are you sure you're not thinking of a Spitzenstein?
That sounds like the product of a lab in a Transylvanian castle. "IT'S ALIVE! IT'S ALIVE!"
You're thinking of the Moldovan Shishkakeeshond, better known as the "Transylvanian Bird Tepes." Similar, but the Spitzenstein has neckbolts, and the Bird Tepes has this really bad habit of literally pointing out birds.

harold · 3 May 2011

jj23 said: http://www.evolutionnews.org/2011/05/president_obama_is_said_to046271.html let's get this posted and start shredding klinghoffer's silly arguements...
Klinghoffer is a complete jackass. 1) The fact that the sequences of non-coding DNA regions aren't subject to the same high selection pressure as the sequences of vital genes makes them better for testing relationships between individuals. It allows more diversity to be present at those loci. That's just basic. So this lying sack of crap has it all backwards in the most basic way. The fact that they are useful for testing relationships between individuals is itself strong evidence that the exact sequence of these regions is not important for viability. 2) The mechanisms by which much of the DNA got there are well understood, e.g. ERVs, etc. These DNA sequences by definition did not originate as "designed" sequences to be of use to humans. 3) Nevertheless, it is a straw man of the grossest order to claim that mainstream scientists claim that no non-coding DNA could have any function whatsoever. Indeed, to call it a straw man is an insult to better constructed straw men. Mice develop perfectly normally without it, for example, http://www.nature.com/news/2004/041018/full/news041018-7.html, yet the presence or absence of some non-coding DNA may have subtle but important phenotypic effects http://www.nature.com/news/2010/100221/full/news.2010.82.html. 4) The existence of non-coding DNA virtually demolishes ID/creationism, even if that aspect of biology is considered in isolation. Hence the understandable squealing panic with which ID/creationist douchebags respond to any mention of it (even, in this case, routine laboratory DNA testing). However, the converse does not hold true. Even though non-coding DNA unequivocally exists, virtually proving that ID/creationist religion and philosophy are patently false and that their lives are empty shells of delusion, denial, and hypocrisy, the converse does not hold. The theory of evolution does not "require" any particular type of non-coding DNA. In fact, the haploid genomes of prokaryotes contain essentially no DNA that is not directly regulatory or coding, despite the fact that they evolved.

Paul Burnett · 3 May 2011

Klaus Hellnick said: Puffins use their wings to swim; cormorants use their feet.
At the Monterey Bay Aquarium in California, the 1.2 million gallon tank has a huge window so folks can watch the fish. At feeding time, the local Common Murres (Uria aalge) occasionally sneak in and feed among the fish. It's startling to be watching all these fish and see a bird fly by. Watching a murre swim with its wings makes it easier to understand penguin evolution.

Michael J · 3 May 2011

I don't think that having all DNA code for something is necessary for ID either. Given that how they love to mis-use 2SLOT the idea that we once had perfect DNA but after the fall our DNA is deteriorating could just as easy fit into their non-theory. I think that they are eventually going to regret the decision to make this an issue.
harold said:
jj23 said: http://www.evolutionnews.org/2011/05/president_obama_is_said_to046271.html let's get this posted and start shredding klinghoffer's silly arguements...
Klinghoffer is a complete jackass. 1) The fact that the sequences of non-coding DNA regions aren't subject to the same high selection pressure as the sequences of vital genes makes them better for testing relationships between individuals. It allows more diversity to be present at those loci. That's just basic. So this lying sack of crap has it all backwards in the most basic way. The fact that they are useful for testing relationships between individuals is itself strong evidence that the exact sequence of these regions is not important for viability. 2) The mechanisms by which much of the DNA got there are well understood, e.g. ERVs, etc. These DNA sequences by definition did not originate as "designed" sequences to be of use to humans. 3) Nevertheless, it is a straw man of the grossest order to claim that mainstream scientists claim that no non-coding DNA could have any function whatsoever. Indeed, to call it a straw man is an insult to better constructed straw men. Mice develop perfectly normally without it, for example, http://www.nature.com/news/2004/041018/full/news041018-7.html, yet the presence or absence of some non-coding DNA may have subtle but important phenotypic effects http://www.nature.com/news/2010/100221/full/news.2010.82.html. 4) The existence of non-coding DNA virtually demolishes ID/creationism, even if that aspect of biology is considered in isolation. Hence the understandable squealing panic with which ID/creationist douchebags respond to any mention of it (even, in this case, routine laboratory DNA testing). However, the converse does not hold true. Even though non-coding DNA unequivocally exists, virtually proving that ID/creationist religion and philosophy are patently false and that their lives are empty shells of delusion, denial, and hypocrisy, the converse does not hold. The theory of evolution does not "require" any particular type of non-coding DNA. In fact, the haploid genomes of prokaryotes contain essentially no DNA that is not directly regulatory or coding, despite the fact that they evolved.

Karen S. · 4 May 2011

I don’t think that having all DNA code for something is necessary for ID either. Given that how they love to mis-use 2SLOT the idea that we once had perfect DNA but after the fall our DNA is deteriorating could just as easy fit into their non-theory.
That's it in a nutshell. What wouldn't fit into their non-theory?

harold · 4 May 2011

Michael J. -
I don’t think that having all DNA code for something is necessary for ID either. Given that how they love to mis-use 2SLOT the idea that we once had perfect DNA but after the fall our DNA is deteriorating could just as easy fit into their non-theory
That is a very good point. However - 1) We have to differentiate between open YEC and ID. Open YEC is incorrect and associated with a lot of severe dishonesty such as repeating points that have been proven wrong, grossly misrepresenting the views of critics, falsely accusing critics of outrageous things, etc. But it is internally coherent and does not hide its own ultimate claims about who designed what and when. ID, meanwhile, is (or was) basically a ruse to "court proof" creationism, by dissembling about the religious content and focusing exclusively on evolution denial. Therefore, they can't talk about "the fall", which is probably why they don't. 2) Relatedly, I have to take the word of ID advocates as to what fits with ID. It's very kind of you to suggest to them that non-coding DNA "could fit" with their "theory" :), but that's not how they treat the subject. They persistently deny the nature of non-coding DNA. 3) Another point is that non-coding DNA in eukaryotes offers a lot of very strong independent evidence for evolution, ERVs being a very obvious example (but just one of many). It's important to recall that ID isn't merely theistic evolution or even Last Thursdayism - the raison d'etre of ID is evolution denial. So non-coding DNA is quite a problem for them.

John Harshman · 4 May 2011

The last several posters have used the term "non-coding DNA" when they meant "junk DNA". People, they mean something quite different. Non-coding DNA is just that: it isn't translated to amino acids via the genetic code. Junk DNA is just that: DNA with no function in the organism. There is a fair amount of non-coding DNA that isn't junk. Confusion on this point plays into the hands of creationists, whose strawman argument is that since (as they wrongly claim) all non-coding DNA was once considered junk, finding any function in any non-coding DNA proves that there is no junk.

Joe Felsenstein · 4 May 2011

Karen S. said:
I don’t think that having all DNA code for something is necessary for ID either. Given that how they love to mis-use 2SLOT the idea that we once had perfect DNA but after the fall our DNA is deteriorating could just as easy fit into their non-theory.
That's it in a nutshell. What wouldn't fit into their non-theory?
The problem is that the ID types are trying to have it both ways with respect to “junk” DNA: 1. They are adamant that you cannot make “bad design” arguments against ID as you cannot know the intentions of the Designer(s). 2. At the same time, they insist that ID makes a prediction that there will be no DNA that is junk. The latter seems to be a no-bad-design argument! It would be interesting to see if they can say where in ID “theory” the prediction comes from. Certainly not from the work of Dembski, who is not dealing with this issue. Certainly not from the work of Behe, who is also not dealing with this issue. So where does their supposed prediction come from? It looks an awful lot like a good-design argument, although they insist we cannot hold them to a good-design position. So where else could it possibly come from? They are curiously silent on that.

harold · 4 May 2011

John Harshman said: The last several posters have used the term "non-coding DNA" when they meant "junk DNA". People, they mean something quite different. Non-coding DNA is just that: it isn't translated to amino acids via the genetic code. Junk DNA is just that: DNA with no function in the organism. There is a fair amount of non-coding DNA that isn't junk. Confusion on this point plays into the hands of creationists, whose strawman argument is that since (as they wrongly claim) all non-coding DNA was once considered junk, finding any function in any non-coding DNA proves that there is no junk.
You are not incorrect to argue in favor of the usage "junk DNA" (that is a matter of subjective preference), but you are very incorrect to imply that the use of "non-coding DNA" as a synonym, by those who know what they are talking about, as I do, is not common. If you search for "junk DNA review" on PubMed you will find that the term is used with qualifiers and quotations marks (e.g. "so-called 'junk' DNA"), or that the term non-coding DNA is also used. If you search Wikipedia for "junk DNA", you will be directed to a well-written article, with plenty of good citations. The title of the article is "Non-Coding DNA". I am keenly aware of the difference between "non-coding" DNA that is actually a regulatory element of a gene, and DNA sequences that are not directly involved in gene expression in any known way. (With the caveat that some types of DNA labeled "junk" or "non-coding" do seem to have effects on phenotype, either through mRNA or possible protein products.) However, I have the choice between two imperfect terms. "Junk" DNA, which is a term I don't like, as it is both excessively colloquial and imprecise (there are, in fact, many active genes which are also not required for normal development or health as well, are they "junk"?), and "non-coding", which is also imprecise. Of those two terms, I choose to use the term "non-coding DNA"; the choice is largely aesthetic and subjective. In this context, it is implied that I am not talking about regulatory elements of genes when I use that term. I am surprised by your unwarranted accusation of ignorance. The content of my prior comments should have made it clear that I am somewhat informed on this topic. The mild controversy over whether "junk" or "non-coding" is better will resolve itself with time. Arguably, both will become anachronistic. From a scientific perspective, it is already usually better to use a precise term like ERVs, LINES, SINES, pseudogenes, etc. At any rate, the important point is that Klinghoffer's statements are nonsense. They are now the topic of a thread at Pharyngula, where the same points I raised about sequence diversity are brought up independently by PZ Myers.

jj23 · 4 May 2011

Harold.....thanks for the postings. I fight the evolution battle in Texas, a continuous task, having info to answer the silly things brought up by the "creos" and wingnuts is always helpful !!

Daoud M'Bo · 4 May 2011

Thanks for posting this, very enjoyable!

Mike Elzinga · 4 May 2011

Joe Felsenstein said: The problem is that the ID types are trying to have it both ways with respect to “junk” DNA: 1. They are adamant that you cannot make “bad design” arguments against ID as you cannot know the intentions of the Designer(s). 2. At the same time, they insist that ID makes a prediction that there will be no DNA that is junk.
One of the common underlying threads in ID/creationist arguments is the denial that scientific laws are capable of producing complex living organisms. Yet, going as far back as the ancient Greeks, people noticed patterns in Nature and wondered about underlying mechanisms (e.g., atoms). The history of science has been one of noticing patterns and behaviors that have become observable in Nature and then digging down to find out why. Reductionist kinds of thinking evolved from the experience that one can “take things apart” and find out how and why they work the way they do. This gets followed up by reconstructing and synthesizing the underlying rules to see if they really work and to learn what they predict. On the other hand, ID/creationists started out by denying that the rules discovered by scientific research explain what we observe. They have to do this because these rules conflict with their prior commitment to sectarian dogma. However, in doing this, they have to make up rules that agree with sectarian dogma that then conflict with what is actually observed; thus the contorted argumentation and apologetics for their “science.” ID/creationist thinking is authoritative and top down. Their rules come first, and if these rules don’t match up with what is actually observed, then what is observed is changed to agree with their rules. Science has generally gone the opposite direction; observe and catalogue what is, and then take it apart to find out how and why it works.

mrg · 4 May 2011

The basic concept behind creationism in all its forms is that "complexity is not part of the natural order of the Universe." If we observe the Universe, complexity certainly seems to be there, and since we only know about the Universe to the extent that we observe it, we have every reason to accept that
fact; but
creationists arbitrarily set off significant components as "unexplainable by natural law" -- that is, "magical".

Once upon a time, life processes were seen as "magical", due to "elan vital", but nobody does so any more. The lessons of the past, or for that matter any lessons, do not make much impression on the critics.

harold · 4 May 2011

jj23 said: Harold.....thanks for the postings. I fight the evolution battle in Texas, a continuous task, having info to answer the silly things brought up by the "creos" and wingnuts is always helpful !!
Thank you, that is most appreciated. I first found out about organized, political creationism in 1999. I have been arguing with them ever since. I think it is an important battle. Basic constitutional rights, and the increasingly unpopular activity of actually accepting basic reality, are at stake here. (I think there is plenty of hope for Texas. Things have been looking grim there for a while, but it is still a diverse state with some of the strongest research institutions in the country.)

John Harshman · 4 May 2011

harold said: You are not incorrect to argue in favor of the usage "junk DNA" (that is a matter of subjective preference), but you are very incorrect to imply that the use of "non-coding DNA" as a synonym, by those who know what they are talking about, as I do, is not common.
It may be common, but I haven't seen it used that way in the primary literature. And if it is, it would be a bad thing. They are most certainly not synonyms unless you think that all non-coding DNA is non-functional. And that's the creationist strawman I'm trying to avoid reinforcing. By the way, I'm not accusing you of ignorance; I'm accusing you (if that's the word) of misusing a term in ways that would encourage a creationist reader to get the wrong idea.
If you search for "junk DNA review" on PubMed you will find that the term is used with qualifiers and quotations marks (e.g. "so-called 'junk' DNA"), or that the term non-coding DNA is also used. If you search Wikipedia for "junk DNA", you will be directed to a well-written article, with plenty of good citations. The title of the article is "Non-Coding DNA".
And yet, as the article makes clear, "Non-Coding DNA" doesn't mean what you were using it for, i.e. DNA without function.
I am keenly aware of the difference between "non-coding" DNA that is actually a regulatory element of a gene, and DNA sequences that are not directly involved in gene expression in any known way. (With the caveat that some types of DNA labeled "junk" or "non-coding" do seem to have effects on phenotype, either through mRNA or possible protein products.)
Note that regulatory elements of genes do not exhaust the category of functional non-coding DNA. And in the paragraph just above you're still using "junk" and "non-coding" as synonyms. I think this is a bad idea.
However, I have the choice between two imperfect terms. "Junk" DNA, which is a term I don't like, as it is both excessively colloquial and imprecise (there are, in fact, many active genes which are also not required for normal development or health as well, are they "junk"?), and "non-coding", which is also imprecise.
Of course "junk" is precise. Nobody says that functional DNA has to be necessary for life. The requirement is that it has a function. And a pretty good sign of function is some degree of evolutionary conservation. Further, your idea that there are only two terms available is odd. You could, for example, coin a new term. How about "non-functional DNA"? (I'm personally fine with "junk", since it has a clear meaning. If you don't like the colloquial, you must hate geneticists' names for genes -- "sonic hedgehog", anyone?)
At any rate, the important point is that Klinghoffer's statements are nonsense.
Of course they are. I wasn't complaining about anything other than your use of a term in a way I consider pernicious.
They are now the topic of a thread at Pharyngula, where the same points I raised about sequence diversity are brought up independently by PZ Myers.
Did PZ use "non-coding" as a synonym for "junk"?

John Harshman · 4 May 2011

By the way, Larry Moran's comments on junk DNA and Jonathan Wells are a good summary of my position, since I agree with Larry about everything he says there.

[Side note: is there a rule that you can't embed more than one link per post? I tried and there is claimed to be a syntax error. Larry has two other posts on the subject.]

Mike Elzinga · 4 May 2011

The latest example of the inability of ID/creationists to understand the use of analogy and metaphor in science is posted over on AiG.

We can at least credit ID/creationists for teaching Lee Attwater, Karl Rove, the birthers, the Koch brothers, and Faux News how to word-game and twist anything in order to kick up dust and sand and cloud the issues.

It may not be such a bad thing that the small child thinking of ID/creationists has alerted members of the science community to articulate scientific concepts more carefully when addressing the public as well as students. But it is no reason for ID/creationists to celebrate their own juvenile thought processes.

harold · 4 May 2011

John Harshman -

Fine, let's not be like creationists, but rather, acknowledge one another's viewpoints correctly, and possibly even arrive at a consensus.

We have a strong point of agreement. Poorly defined terminology is undesirable. One of the many reasons why it is undesirable is that creationists seize upon it to sew confusion. I will concede that "non-coding DNA" is too general a term.

The opinionated but knowledgeable and articulate Lary Moran makes a good point.

However, others have made exactly the opposite point, and expressed dislike of the term "junk". http://www.scientificamerican.com/article.cfm?id=what-is-junk-dna-and-what

I suppose what bothers me about the term "junk" is not that it is colloquial, but that to me it has a teleological or anthropomorphic flavor.

However, you are correct that greater precision is better. While I personally won't be using the term "junk" without qualification, or anywhere where a better or more precise term will do, I will try to be especially clear as to what I am talking about in the future. To be honest, I was so astounded by Klinghoffer's ignorant comments that I wrote my original comment rather rapidly, and I didn't bother to mull over which term to use.

There is still a trivial, subjective disagreement between us, which cannot be resolved, but is of little importance. While I'm sure we completely agree on which parts of the genome are subjected to strong selective pressure/conservation, which parts aren't, and so on, you like the term "junk DNA" for certain elements of the genome, and I don't like it (but now concede that use the term "non-coding DNA" instead as a synonym is probably even worse).

Finally, I will close with some predictions -

1) Obviously, some elements of the genome have essentially no "function", that is to say, significant impact on the phenotype, and will never be found to have any.

2) Some elements of the genome that are currently poorly understood will turn out to have, if not "function" in a classic sense, impact on the phenotype.

3) When "2)" happens, creationists will falsely claim that scientists claimed that these DNA regions could not ever have any impact on the phenotype. There is nothing we can do to stop them, and indeed, using the term "junk" only makes them more likely to do this, but after they do it, we can correctly point out that no such claims by scientists were ever made. (Klinghoffer is not even at this level of sophistication; his absurd argument amounts to claiming that the fact that first degree relatives have sequence similarity at highly variable, not-selection-constrained sequence regions is a "function" for those regions, or some such thing.)

hoary puccoon · 4 May 2011

harold said: Poorly defined terminology is undesirable. One of the many reasons why it is undesirable is that creationists seize upon it to sew [sic] confusion.
Well, yes. That would be "sow" confusion-- as is spreading seeds of confusion. Which is exactly what you're not trying to do, right? ;)

Rolf Aalberg · 4 May 2011

1) and 2); quite reasonable to expect. As for 3), I am afraid we will have to endure that for yet some time.

John Harshman · 4 May 2011

harold said: Fine, let's not be like creationists, but rather, acknowledge one another's viewpoints correctly, and possibly even arrive at a consensus.
So we are agreed that "non-coding" is not the term to use. If you don't like "junk", I suggest you invent a new term. I've suggested "non-functional", but feel free to roll your own. And whatever you call it, there's plenty of it in your genome. My rough estimate of 90% is predicated on the observation that fugu are doing just fine with a genome 1/10 the size of yours, and yet seem to have about the same number of genes and about the same "complexity". I bet fugu have some junk too, so the estimate is a minimum. And most of your genome just isn't conserved.

harold · 4 May 2011

hoary puccoon said:
harold said: Poorly defined terminology is undesirable. One of the many reasons why it is undesirable is that creationists seize upon it to sew [sic] confusion.
Well, yes. That would be "sow" confusion-- as is spreading seeds of confusion. Which is exactly what you're not trying to do, right? ;)
Yes, you are correct, it would be "sow".

harold · 4 May 2011

So we are agreed that "non-coding" is not the term to use. If you don't like "junk", I suggest you invent a new term. I've suggested "non-functional", but feel free to roll your own.
I will probably stick to current terms, but use them in a very precise way to avoid both confusion and semantic debates.
And whatever you call it, there's plenty of it in your genome. My rough estimate of 90% is predicated on the observation that fugu are doing just fine with a genome 1/10 the size of yours, and yet seem to have about the same number of genes and about the same "complexity". I bet fugu have some junk too, so the estimate is a minimum. And most of your genome just isn't conserved.
Yes, I am aware of that. And the Marbled Lungfish presumably has much more so-called "junk" DNA that I do. I pride myself on being just as "complex" as they are. http://en.wikipedia.org/wiki/Protopterus_aethiopicus

Hygaboo Andersen · 4 May 2011

harold said:
jj23 said: http://www.evolutionnews.org/2011/05/president_obama_is_said_to046271.html let's get this posted and start shredding klinghoffer's silly arguements...
Klinghoffer is a complete jackass. 1) The fact that the sequences of non-coding DNA regions aren't subject to the same high selection pressure as the sequences of vital genes makes them better for testing relationships between individuals. It allows more diversity to be present at those loci. That's just basic. So this lying sack of crap has it all backwards in the most basic way. The fact that they are useful for testing relationships between individuals is itself strong evidence that the exact sequence of these regions is not important for viability. 2) The mechanisms by which much of the DNA got there are well understood, e.g. ERVs, etc. These DNA sequences by definition did not originate as "designed" sequences to be of use to humans. 3) Nevertheless, it is a straw man of the grossest order to claim that mainstream scientists claim that no non-coding DNA could have any function whatsoever. Indeed, to call it a straw man is an insult to better constructed straw men. Mice develop perfectly normally without it, for example, http://www.nature.com/news/2004/041018/full/news041018-7.html, yet the presence or absence of some non-coding DNA may have subtle but important phenotypic effects http://www.nature.com/news/2010/100221/full/news.2010.82.html. 4) The existence of non-coding DNA virtually demolishes ID/creationism, even if that aspect of biology is considered in isolation. Hence the understandable squealing panic with which ID/creationist douchebags respond to any mention of it (even, in this case, routine laboratory DNA testing). However, the converse does not hold true. Even though non-coding DNA unequivocally exists, virtually proving that ID/creationist religion and philosophy are patently false and that their lives are empty shells of delusion, denial, and hypocrisy, the converse does not hold. The theory of evolution does not "require" any particular type of non-coding DNA. In fact, the haploid genomes of prokaryotes contain essentially no DNA that is not directly regulatory or coding, despite the fact that they evolved.
The problem is the evolanders simply assume the existence of non-coding DNA that they assume neutral with respect to selection and then construct their phylogenetic trees based on the question-begging assumptions of their own religion. What is there is no real junk DNA? What if common descent was just the foregone conclusion and the so-called "neutral" genes were chosen in order to reach this conclusion? Questioning the dogma of Junk DNA can bring the House of Darwin down just like Elijah did to the prophets of Baal (the Darwin of his day) on Mt. Carmel!

Sylvilagus · 4 May 2011

Hygaboo Andersen said:
harold said:
jj23 said: http://www.evolutionnews.org/2011/05/president_obama_is_said_to046271.html let's get this posted and start shredding klinghoffer's silly arguements...
Klinghoffer is a complete jackass. 1) The fact that the sequences of non-coding DNA regions aren't subject to the same high selection pressure as the sequences of vital genes makes them better for testing relationships between individuals. It allows more diversity to be present at those loci. That's just basic. So this lying sack of crap has it all backwards in the most basic way. The fact that they are useful for testing relationships between individuals is itself strong evidence that the exact sequence of these regions is not important for viability. 2) The mechanisms by which much of the DNA got there are well understood, e.g. ERVs, etc. These DNA sequences by definition did not originate as "designed" sequences to be of use to humans. 3) Nevertheless, it is a straw man of the grossest order to claim that mainstream scientists claim that no non-coding DNA could have any function whatsoever. Indeed, to call it a straw man is an insult to better constructed straw men. Mice develop perfectly normally without it, for example, http://www.nature.com/news/2004/041018/full/news041018-7.html, yet the presence or absence of some non-coding DNA may have subtle but important phenotypic effects http://www.nature.com/news/2010/100221/full/news.2010.82.html. 4) The existence of non-coding DNA virtually demolishes ID/creationism, even if that aspect of biology is considered in isolation. Hence the understandable squealing panic with which ID/creationist douchebags respond to any mention of it (even, in this case, routine laboratory DNA testing). However, the converse does not hold true. Even though non-coding DNA unequivocally exists, virtually proving that ID/creationist religion and philosophy are patently false and that their lives are empty shells of delusion, denial, and hypocrisy, the converse does not hold. The theory of evolution does not "require" any particular type of non-coding DNA. In fact, the haploid genomes of prokaryotes contain essentially no DNA that is not directly regulatory or coding, despite the fact that they evolved.
The problem is the evolanders simply assume the existence of non-coding DNA that they assume neutral with respect to selection and then construct their phylogenetic trees based on the question-begging assumptions of their own religion. What is there is no real junk DNA? What if common descent was just the foregone conclusion and the so-called "neutral" genes were chosen in order to reach this conclusion? Questioning the dogma of Junk DNA can bring the House of Darwin down just like Elijah did to the prophets of Baal (the Darwin of his day) on Mt. Carmel!
Well, when phylogenetic trees are constructed there are statistical tests to determine the reliability of the constructions. Just like any attempt to fit data to a line. If the statistical measures fall outside of certain bounds the data is not a good fit to the line. Same, more or less with construction of trees. In other words, constructing the trees is not based on "assumption" of common descent; construction of the trees actually tests common descent. If common descent were not the case, we would not find trees constructed from distinct data sets converging statistically on the same tree. We would not find trees constructed from DNA, from numerous proteins, and from morphology all converging. How do you explain the convergence of these distinct trees if not common descent?

Hygaboo Andersen · 4 May 2011

Sylvilagus said:
Hygaboo Andersen said:
harold said:
jj23 said: http://www.evolutionnews.org/2011/05/president_obama_is_said_to046271.html let's get this posted and start shredding klinghoffer's silly arguements...
Klinghoffer is a complete jackass. 1) The fact that the sequences of non-coding DNA regions aren't subject to the same high selection pressure as the sequences of vital genes makes them better for testing relationships between individuals. It allows more diversity to be present at those loci. That's just basic. So this lying sack of crap has it all backwards in the most basic way. The fact that they are useful for testing relationships between individuals is itself strong evidence that the exact sequence of these regions is not important for viability. 2) The mechanisms by which much of the DNA got there are well understood, e.g. ERVs, etc. These DNA sequences by definition did not originate as "designed" sequences to be of use to humans. 3) Nevertheless, it is a straw man of the grossest order to claim that mainstream scientists claim that no non-coding DNA could have any function whatsoever. Indeed, to call it a straw man is an insult to better constructed straw men. Mice develop perfectly normally without it, for example, http://www.nature.com/news/2004/041018/full/news041018-7.html, yet the presence or absence of some non-coding DNA may have subtle but important phenotypic effects http://www.nature.com/news/2010/100221/full/news.2010.82.html. 4) The existence of non-coding DNA virtually demolishes ID/creationism, even if that aspect of biology is considered in isolation. Hence the understandable squealing panic with which ID/creationist douchebags respond to any mention of it (even, in this case, routine laboratory DNA testing). However, the converse does not hold true. Even though non-coding DNA unequivocally exists, virtually proving that ID/creationist religion and philosophy are patently false and that their lives are empty shells of delusion, denial, and hypocrisy, the converse does not hold. The theory of evolution does not "require" any particular type of non-coding DNA. In fact, the haploid genomes of prokaryotes contain essentially no DNA that is not directly regulatory or coding, despite the fact that they evolved.
The problem is the evolanders simply assume the existence of non-coding DNA that they assume neutral with respect to selection and then construct their phylogenetic trees based on the question-begging assumptions of their own religion. What is there is no real junk DNA? What if common descent was just the foregone conclusion and the so-called "neutral" genes were chosen in order to reach this conclusion? Questioning the dogma of Junk DNA can bring the House of Darwin down just like Elijah did to the prophets of Baal (the Darwin of his day) on Mt. Carmel!
Well, when phylogenetic trees are constructed there are statistical tests to determine the reliability of the constructions. Just like any attempt to fit data to a line. If the statistical measures fall outside of certain bounds the data is not a good fit to the line. Same, more or less with construction of trees. In other words, constructing the trees is not based on "assumption" of common descent; construction of the trees actually tests common descent. If common descent were not the case, we would not find trees constructed from distinct data sets converging statistically on the same tree. We would not find trees constructed from DNA, from numerous proteins, and from morphology all converging. How do you explain the convergence of these distinct trees if not common descent?
Read for comprehension,moron! It's the so-called junk DNA that is supposedly "neutral" and used in baseline comparisons in these studies that is the assumption. The evolanders needed to construct the junk DNA concept to resolve the contradictions between their previous constructs of natural selection and common ancestry. If natural selection just twists and turns the genome into rubber chickens, you really can't compare how far back so-called lineages split up since there is no neutral yardstick to measure rates of genetic change. However, since natural selection is the cornerstone of the Darwinian faith, it can never be discarded. So,the doctrine of junk DNA had to be invented to square the circle

Mike Elzinga · 4 May 2011

Weird!

mrg · 4 May 2011

I kind of like the comment I once heard about noncoding DNA being the "dark matter" of the genome: "There's something going on here, but we don't understand quite what in more than bits and pieces."

Nice essay by Moran, JH, thanks for the link. Moran takes no prisoners but he's no dummy. I could only read his responses, however; I find it very very hard to read creationists any more -- having someone with killer halitosis blather in my face is bad enough, going out of my way to make it happen is unacceptable.

Sylvilagus · 4 May 2011

Hygaboo Andersen said:
Sylvilagus said:
Hygaboo Andersen said:
harold said:
jj23 said: http://www.evolutionnews.org/2011/05/president_obama_is_said_to046271.html let's get this posted and start shredding klinghoffer's silly arguements...
Klinghoffer is a complete jackass. 1) The fact that the sequences of non-coding DNA regions aren't subject to the same high selection pressure as the sequences of vital genes makes them better for testing relationships between individuals. It allows more diversity to be present at those loci. That's just basic. So this lying sack of crap has it all backwards in the most basic way. The fact that they are useful for testing relationships between individuals is itself strong evidence that the exact sequence of these regions is not important for viability. 2) The mechanisms by which much of the DNA got there are well understood, e.g. ERVs, etc. These DNA sequences by definition did not originate as "designed" sequences to be of use to humans. 3) Nevertheless, it is a straw man of the grossest order to claim that mainstream scientists claim that no non-coding DNA could have any function whatsoever. Indeed, to call it a straw man is an insult to better constructed straw men. Mice develop perfectly normally without it, for example, http://www.nature.com/news/2004/041018/full/news041018-7.html, yet the presence or absence of some non-coding DNA may have subtle but important phenotypic effects http://www.nature.com/news/2010/100221/full/news.2010.82.html. 4) The existence of non-coding DNA virtually demolishes ID/creationism, even if that aspect of biology is considered in isolation. Hence the understandable squealing panic with which ID/creationist douchebags respond to any mention of it (even, in this case, routine laboratory DNA testing). However, the converse does not hold true. Even though non-coding DNA unequivocally exists, virtually proving that ID/creationist religion and philosophy are patently false and that their lives are empty shells of delusion, denial, and hypocrisy, the converse does not hold. The theory of evolution does not "require" any particular type of non-coding DNA. In fact, the haploid genomes of prokaryotes contain essentially no DNA that is not directly regulatory or coding, despite the fact that they evolved.
The problem is the evolanders simply assume the existence of non-coding DNA that they assume neutral with respect to selection and then construct their phylogenetic trees based on the question-begging assumptions of their own religion. What is there is no real junk DNA? What if common descent was just the foregone conclusion and the so-called "neutral" genes were chosen in order to reach this conclusion? Questioning the dogma of Junk DNA can bring the House of Darwin down just like Elijah did to the prophets of Baal (the Darwin of his day) on Mt. Carmel!
Well, when phylogenetic trees are constructed there are statistical tests to determine the reliability of the constructions. Just like any attempt to fit data to a line. If the statistical measures fall outside of certain bounds the data is not a good fit to the line. Same, more or less with construction of trees. In other words, constructing the trees is not based on "assumption" of common descent; construction of the trees actually tests common descent. If common descent were not the case, we would not find trees constructed from distinct data sets converging statistically on the same tree. We would not find trees constructed from DNA, from numerous proteins, and from morphology all converging. How do you explain the convergence of these distinct trees if not common descent?
Read for comprehension,moron! It's the so-called junk DNA that is supposedly "neutral" and used in baseline comparisons in these studies that is the assumption. The evolanders needed to construct the junk DNA concept to resolve the contradictions between their previous constructs of natural selection and common ancestry. If natural selection just twists and turns the genome into rubber chickens, you really can't compare how far back so-called lineages split up since there is no neutral yardstick to measure rates of genetic change. However, since natural selection is the cornerstone of the Darwinian faith, it can never be discarded. So,the doctrine of junk DNA had to be invented to square the circle
You clearly don't understand my point or the significance of the multiple independent data sources for phylogenetic trees. The fact that trees constructed from non-DNA data (e.g. morphology and protein sequences) converge on the trees derived from DNA sequences is a test of the neutrality you say is assumed. It's not assumed, it has been tested. I'll repeat my question: how else would you explain the statistical convergences?

Leszek · 5 May 2011

Hygaboo Andersen said:
Sylvilagus said:
Hygaboo Andersen said:
harold said:
jj23 said: http://www.evolutionnews.org/2011/05/president_obama_is_said_to046271.html let's get this posted and start shredding klinghoffer's silly arguements...
Klinghoffer is a complete jackass. 1) The fact that the sequences of non-coding DNA regions aren't subject to the same high selection pressure as the sequences of vital genes makes them better for testing relationships between individuals. It allows more diversity to be present at those loci. That's just basic. So this lying sack of crap has it all backwards in the most basic way. The fact that they are useful for testing relationships between individuals is itself strong evidence that the exact sequence of these regions is not important for viability. 2) The mechanisms by which much of the DNA got there are well understood, e.g. ERVs, etc. These DNA sequences by definition did not originate as "designed" sequences to be of use to humans. 3) Nevertheless, it is a straw man of the grossest order to claim that mainstream scientists claim that no non-coding DNA could have any function whatsoever. Indeed, to call it a straw man is an insult to better constructed straw men. Mice develop perfectly normally without it, for example, http://www.nature.com/news/2004/041018/full/news041018-7.html, yet the presence or absence of some non-coding DNA may have subtle but important phenotypic effects http://www.nature.com/news/2010/100221/full/news.2010.82.html. 4) The existence of non-coding DNA virtually demolishes ID/creationism, even if that aspect of biology is considered in isolation. Hence the understandable squealing panic with which ID/creationist douchebags respond to any mention of it (even, in this case, routine laboratory DNA testing). However, the converse does not hold true. Even though non-coding DNA unequivocally exists, virtually proving that ID/creationist religion and philosophy are patently false and that their lives are empty shells of delusion, denial, and hypocrisy, the converse does not hold. The theory of evolution does not "require" any particular type of non-coding DNA. In fact, the haploid genomes of prokaryotes contain essentially no DNA that is not directly regulatory or coding, despite the fact that they evolved.
The problem is the evolanders simply assume the existence of non-coding DNA that they assume neutral with respect to selection and then construct their phylogenetic trees based on the question-begging assumptions of their own religion. What is there is no real junk DNA? What if common descent was just the foregone conclusion and the so-called "neutral" genes were chosen in order to reach this conclusion? Questioning the dogma of Junk DNA can bring the House of Darwin down just like Elijah did to the prophets of Baal (the Darwin of his day) on Mt. Carmel!
Well, when phylogenetic trees are constructed there are statistical tests to determine the reliability of the constructions. Just like any attempt to fit data to a line. If the statistical measures fall outside of certain bounds the data is not a good fit to the line. Same, more or less with construction of trees. In other words, constructing the trees is not based on "assumption" of common descent; construction of the trees actually tests common descent. If common descent were not the case, we would not find trees constructed from distinct data sets converging statistically on the same tree. We would not find trees constructed from DNA, from numerous proteins, and from morphology all converging. How do you explain the convergence of these distinct trees if not common descent?
Read for comprehension,moron! It's the so-called junk DNA that is supposedly "neutral" and used in baseline comparisons in these studies that is the assumption. The evolanders needed to construct the junk DNA concept to resolve the contradictions between their previous constructs of natural selection and common ancestry. If natural selection just twists and turns the genome into rubber chickens, you really can't compare how far back so-called lineages split up since there is no neutral yardstick to measure rates of genetic change. However, since natural selection is the cornerstone of the Darwinian faith, it can never be discarded. So,the doctrine of junk DNA had to be invented to square the circle
In addition to everything Sylvilagus said, I would like to point out that others have already in this same thread pointed out that it isn't an assumption. We know and understand where much of this junk DNA come from. For example ERV's which are snippets of virus DNA inserted into the gnome at more or less random places. So even though we can't be sure every bit of DNA is useless junk, we can know that much of it is, or at least in humans it is. ERV's also provide excellent evidence for common descent as you can use them to make a tree of life. As Sylvilagus pointed out this tree of life happens to match closely the trees made by many other independent methods some of which are not even genetic. I would refrain from saying things like "Read for comprehension,moron!" because it is clear that you are the one that didn't do the understanding. Unless you are trolling. In that case I give you a 4 on my troll scale. You lost points for lack of style and effect.

Rolf Aalberg · 5 May 2011

However, since natural selection is the cornerstone of the Darwinian faith, it can never be discarded.

Well, since natural selection is such an obvious fact, why and how could it be discarded?

Altair IV · 5 May 2011

I have a "junk drawer" in my kitchen. It's filled with all kinds of things; extra parts, broken pieces, interesting bits of stuff I've picked up in various places. None of it is being kept for what it was originally intended for, but I keep it all around because I think that I might find a use for it someday. And every once-in-a-while I do.*

So even colloquially, "junk" is not perfectly synonymous with "non-functional" or "useless". It just means that it's superfluous for or no longer able to be used in its original capacity.

In the end, I see the creationist "no junk DNA" thing as just an extension of the "no vestigial parts" argument, and for the same basic reasons. They both revolve around using a semantic sleigh-of-hand to build a strawman to attack.

(*Not to imply that junk DNA is being purposely preserved for possible future use, although some creationists might argue it that way.)

Altair IV · 5 May 2011

By the way, there's an interesting description of the etymology of "junk" here: http://www.thefreedictionary.com/junk An excerpt:
First recorded in 1353, the word meant "an old cable or rope." On a sailing ship it made little sense to throw away useful material since considerable time might pass before one could get new supplies.

ben · 5 May 2011

What is there is no real junk DNA? What if common descent was just the foregone conclusion and the so-called “neutral” genes were chosen in order to reach this conclusion?
What if you or any other IDiot were to actually suggest or {GASP!} perform some research to determine this, instead of pretending you've shot critical holes in science's most well-researched and well-supported theory simply by suggesting something you believe might be true? Why is it that the very last thing any IDiot would ever mention is an actual ID research program, and what hypotheses it might look into? You're all just a bunch of armchair quarterbacks who not only know nothing about football but hate it with a passion, think it should be abolished, and believe we should just read the bible to discover who won the Super Bowl.

eric · 5 May 2011

Hygaboo Andersen said: The problem is the evolanders simply assume the existence of non-coding DNA
My understanding is that this is not an assumption, it is a well-tested hypothesis. Meaning that we have removed chunks of genome from various critters, watched them develop, and observed that there is no difference in their development compared to the the controls. No difference = the removed portions have no impact on development = true junk, not merely "unknown function." This is a positive test for junkiness, not a negative test, so when the results come back indicating no difference, we can positively conclude that junk DNA exists. And you only need to find one bit of it to prove the principle. After that, its not a question of whether organisms have junk DNA, its only a question of how much. However, I don't have any citations on such experiments handy, so maybe some other lurker would be kind enough to post links to relevant work.

eric · 5 May 2011

Errr...I just realized hygaboo said "non-coding." The existence of non-coding DNA is experimentally overwhelming, but its a different set of experiments than the ones I talked about in my previous post.

raven · 5 May 2011

However, since natural selection is the cornerstone of the Darwinian faith, it can never be discarded.
Burning fuel is the cornerstone of the Theory of Internal Combustion faith. Gravity is the cornerstone of both the Newtonian faith and the Einsteinian Reformation. We aren't going to discard chemical reactions with oxygen or gravity either.

raven · 5 May 2011

In the end, I see the creationist “no junk DNA” thing as just an extension of the “no vestigial parts” argument, and for the same basic reasons.
It's also an extension of the creationist's "We're completely wrong and lie a lot" arguments. And in the same class as the sun orbiting the earth (Geocentrism), which 26% of the fundies believe. The data that much noncoding DNA is nonfunctional is huge and evergrowing.

harold · 5 May 2011

Some of what is called "junk" DNA can have effects on phenotype under certain circumstances. Such impact may often be "negative" from the human perspective.

http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0030166

http://www.nature.com/news/2010/100221/full/news.2010.82.html

http://www.pnas.org/content/103/39/14390

Yet it is also the case that much of "junk" DNA does not show selection constraints on nucleotide sequence. We can logically infer from this that the exact nucleotide sequences at these sites has at best little impact on phenotype. (Of course, this inference is limited to those aspects of phenotype that could impact on reproductive success. Phenotypic variability that does not effect relative reproductive success cannot be a direct basis for natural selection.)

The relative lack of sequence constraints makes this type of DNA ideal for studies that determine the relationships between individuals or populations. In essence, if you look at genes that perform critical functions, all living individuals are likely have quite similar sequences, because mutations that impact on the amino acid sequence of the protein or the regulation of gene expression (if you look at regulatory sequences) may have consequences that are impacted strongly by natural selection. But if you look at genome regions that don't have this characteristic, there will be more variation from individual to individual, and similar sequences can more confidently be ascribed to genealogical relationship.

Klinghoffer, in the moronic statement that triggered this discussion, essentially made the convoluted claim that forensic use of such sequences to determine genealogical relationship, constitutes a biological "function".

All "junk" DNA is a major, major, major problem for ID/creationism. While it (like anything else that could ever exist) can be accommodated by a "Last Thursdayism" claim that "some incomprehensible and unappealing magical designer did it but made it look exactly like evolution", that's about it. However, both the straightforward claim of YEC - that the biosphere was magically created in about its current form 6000 years ago by a human-like benign deity - and the weaselations of ID - efforts to claim that evolution is "impossible" - are severely challenged by the nature of the genome. The genome contains numerous elements which are well-explained by the theory of evolution and bizarre from the perspective of imagined magical creation by an anthropomorphic magical being.

Hence, ID/creationists obsessively and hysterically deny the existence of "junk" DNA.

However, while I conceded above that "non-coding" DNA is too vague and general a term (and also possibly technically incorrect, depending on what we mean by "coding"), and have used the term "junk" here ("junk" DNA being a subset of what is called "non-coding" DNA), I also think it is possible to overreact to creationists.

Mice have been found to develop normally when lacking large amounts of (but by no means all or even a majority of) "junk" DNA. Both the fact that much of "junk" DNA does not show strong sequence conservation due to natural selection, and the fact that genomes of similar organisms can vary massively in size due to "junk" elements in one lineage but not the other, obviously lead to the logical inference that most of the time, the amount of and sequence of this type of DNA is not selected for. Development, reproductive age viability, and reproduction must therefore usually not be impacted by these features of this type of DNA.

Having said that, when we look at the literature, we do not see an exact-opposite-of-creationism "whatever we currently call 'junk' DNA can never do anything whatsoever" argument supported. Here is the subsequent work of one of the scientists who published a major "mice develop normally after deletion of a fair amount of 'junk' DNA" paper. http://www.ncbi.nlm.nih.gov/pubmed?term=%22Peaston%20AE%22%5BAuthor%5D

Please note that creationists are completely wrong about this type of DNA, and logical explanations are highly compatible with and informed by the theory of evolution. This is true even if phenotypic impact is sometimes possible.

mw · 5 May 2011

I think Dr. Dan Ksepka's presentation is showing archaeology and discovery at it’s best, to find fossil skin and to be able to distinguish colours from present melanosomes and put colour to the form of a penguin is really amazing. I’m not so sure about the artery groves I did see holes where arteries could immerge from on both bones it could be showing that bone could have eroded more than the other.

Hygaboo Andersen · 5 May 2011

eric said: Errr...I just realized hygaboo said "non-coding." The existence of non-coding DNA is experimentally overwhelming, but its a different set of experiments than the ones I talked about in my previous post.
How can you prove a universal negative. You just don't know what the DNA codes for. It's just like Richard Dawkins trying to disprove the existence of God because he couldn't find him in his Tea & Crumpets.

Robin · 5 May 2011

Hygaboo Andersen said:
eric said: Errr...I just realized hygaboo said "non-coding." The existence of non-coding DNA is experimentally overwhelming, but its a different set of experiments than the ones I talked about in my previous post.
How can you prove a universal negative. You just don't know what the DNA codes for. It's just like Richard Dawkins trying to disprove the existence of God because he couldn't find him in his Tea & Crumpets.
That would be a demonstration of not thinking about the subject or your question before you asked it. Indeed in a completely parameterless scenario such as "places [a] god could hide", it would be disingenuous to conclude said god's existence after checking only a few places. However, in the case of junk DNA, there is actually a finite (and quite limited, depending on the organism) set of parameters said DNA could possibly code for. By testing those and further testing the development of organisms without that DNA altogether and witnessing no differences, it is safe to conclude that the DNA is junk. Your comparison of apples (some god's potential hiding place) and oranges (parameters of DNA coding) is thus found to be moot.

harold · 5 May 2011

Hygaboo Andersen said:
eric said: Errr...I just realized hygaboo said "non-coding." The existence of non-coding DNA is experimentally overwhelming, but its a different set of experiments than the ones I talked about in my previous post.
How can you prove a universal negative. You just don't know what the DNA codes for. It's just like Richard Dawkins trying to disprove the existence of God because he couldn't find him in his Tea & Crumpets.
People, Hygaboo Andersen is a somewhat talented parody poster who has imitated "fire and brimstone" preachers in the past but is imitating a weasely "Intelligent Design" type today, but anyway - We actually do know what some "junk" DNA codes for. Some of it codes for viral sequences or for a reverse transcriptase enzyme that causes it to endlessly replicate itself and reinsert itself into the genome, for example. While I oppose the oversimplification of assuming that none of it ever has any effect on phenotype under any circumstances, we certainly know that much of it is not usually transcribed, that the sequence and volume of much of it is not subject to much if anything in the way of selective constraints, and that a fair amount of it can be removed from mice without preventing normal development.

eric · 5 May 2011

Hygaboo Andersen said: How can you prove a universal negative. You just don't know what the DNA codes for.
. You take two clones at the earliest stages of development. You knock out the sequence in question from one of them. You grow them. If there's no difference in final state, then you have empirical evidence that the sequence didn't contribute to development. Not 'unknown contribution' but 'observed to have NO contribution.' We have been doing knockout experiments for various species for, what decades now? This is not some new scientific discovery, it is (like many things) a pretty well accepted one that creationists simply choose to pretend never happened. Nature has even done this test for us. It is now known as the 'onion test.' There are several closely-related varieties of onions that have radically different-sized genomes; some twice as big as the other (and pratically all of these onion varieties having genomes larger than the human genome). Anyone who thinks the 'extra' genetic material does something is going to have to explain why both the short and long versions produce pretty much the same onion.

steve p. · 5 May 2011

eric said:
Hygaboo Andersen said: How can you prove a universal negative. You just don't know what the DNA codes for.
. You take two clones at the earliest stages of development. You knock out the sequence in question from one of them. You grow them. If there's no difference in final state, then you have empirical evidence that the sequence didn't contribute to development. Not 'unknown contribution' but 'observed to have NO contribution.' We have been doing knockout experiments for various species for, what decades now? This is not some new scientific discovery, it is (like many things) a pretty well accepted one that creationists simply choose to pretend never happened. Nature has even done this test for us. It is now known as the 'onion test.' There are several closely-related varieties of onions that have radically different-sized genomes; some twice as big as the other (and pratically all of these onion varieties having genomes larger than the human genome). Anyone who thinks the 'extra' genetic material does something is going to have to explain why both the short and long versions produce pretty much the same onion.
Knock-out experiments are a poor way at attempting confirmation of the non-functionality of a particular segment of DNA. Its like kicking a turtle shell, and not seeing any legs or head popping out and declaring, "there's nobody home'. Here is a more an apt analogy in a real-world scenario. In currency trading, there are soft-eng that design robot traders. I put one on the Eur/USD. It only trades 10~2 GMT. Its half-way into the its alotted time window. So far nothing has happened. Should I conclude that 1) it doesn't work or 2) the parameters that trigger an entry point have not been met? From an ND POV you could not consider the second option since you could not entertain the idea of DNA segments being triggered by anything since you have not found any evidence for trigger parameters/mechanisms. So of course, a knockout experiment would lead you to conclude that the DNA has no function. As a proponent of ID, I would not rule out option 2. More over, I would see 2 as viable and probable since we have "overwhelming evidence" biological processes are uncannily like software thus parameters and trigger mechanisms for DNA segments would be likely. Heck, cells have been discovered to possess wireless comms capabilities. Why would trigger params and mechs be out of the question? "The trend is your friend".

steve p. · 6 May 2011

Altair IV said: I have a "junk drawer" in my kitchen. It's filled with all kinds of things; extra parts, broken pieces, interesting bits of stuff I've picked up in various places. None of it is being kept for what it was originally intended for, but I keep it all around because I think that I might find a use for it someday. And every once-in-a-while I do.* So even colloquially, "junk" is not perfectly synonymous with "non-functional" or "useless". It just means that it's superfluous for or no longer able to be used in its original capacity. In the end, I see the creationist "no junk DNA" thing as just an extension of the "no vestigial parts" argument, and for the same basic reasons. They both revolve around using a semantic sleigh-of-hand to build a strawman to attack. (*Not to imply that junk DNA is being purposely preserved for possible future use, although some creationists might argue it that way.)
Altair, you have that stuff in the drawer precisely because you know those things are 'potentially' useful. All what is needed is a trigger to be initiated by having just the right parameters being met. The cost/benefit ratio of holding those things is acceptably low. Otherwise, you would have put them in the trash can, not the junk box, ages ago. This is not to say that all the pieces in your junk box will ever be used, but since it gives you piece of mind in knowing that you have all the stuff you need to bridge potential difficulities, you're keeping it all is worth any inconvenience, hassle in lugging it around. That junk is you friend, your pennies for a rainy day. So I suggest renaming JUNK DNA 'Water Spider' DNA, or Spider DNA for short. This comes from a position held in a garment factory production line. The job description for that position is to be at the ready to assist in any condition required, ie a worker suddenly gets sick, a machine suddely breaks down, increased production speed increases defect rate needing particular attention, etc. etc. The water spider is a jack-of-all-trades position. So its quite apt for what we know as non-coding DNA. It is at the ready for regulatory purposes and at the ready to be used for any new conditions that may arise that calls for modifications/alterations.

Mike Elzinga · 6 May 2011

More weirdness.

Robert Byers · 6 May 2011

erica h-g said:
Robert Byers said: However the idea of in betweens between winging it and flipping it needs evidence. I say its impossible.
I wonder if this fellow watched the presentation, or is simply riffing on the title. The speaker talks in detail about the transition from aerial to underwater flight, with lots of examples of living and extinct birds that are capable of both. More on topic, I noticed that the speaker uses the word "penguin" to refer not only to the body plan and lifestyle of the birds we all know and love, but also to the evolutionary lineage that includes volant birds. Now I am curious about what features might clue us in to recognizing a flighted penguin in the fossil record!
This is about Penguins and not other birds. there are no intermediate fossils of penguins because they changed instantly. There were probably normal flying penguins and swimming/flying penguins. Yet none would be intermediate. Adaptation must be be from innate triggers in the great biological systems in life. No evidence is presented to persuade that penguins evolved by steps from A to B. its speculation upon presumptions already accepted by the audience that he presents these ideas too. flightless birds was very common thousands of years and still are around. The penguin is simply around more because of its extreme areas in lives in. It managed to survived.

Dave Luckett · 6 May 2011

Only Byers could use an expression like "normal flying penguins" with an apparently straight face. Bravo, Robert! A welcome return to form.

robert van bakel · 6 May 2011

Hooray, examples of all three known species of ostriches in one post. The 'I love living with my head in the sand and you should join me' type; Bob Byers.The 'I don't know I'm living with my head in the sand and get the fuck down here with me' type; Hygaboo Anderson. And the long waited for, 'I am living with my head in the sand but think I'm soaring in the skies' type;Steve P.

DS · 6 May 2011

Robert,

As the video demonstrates and as I pointed out before, there are fifty different intermediates forms in the fossil record between flying birds and modern penguins. How do you explain this? Did you actually watch the video? Do you actually have anything but your own personal incredulity as an argument? If not, then I don't believe that you are really a YEC and that means you aren't one. See how easy that was. Your opinion is the only thing that can change instantly and I don't see any evidence of that either.

Steve,

You have committed the logical fallacy of assuming the conclusion. If there is actually no intelligence actively protecting the "junk" then there is no reason whatsoever for it not to stick around, even if it has no function, even if it has no potential function, even if it is potentially harmful. That is what we see in the human genome. Not that that has anything to do with the fifty intermediate penguin species that you and Robert are ignoring.

If you want to claim that all "junk" DNA has a function, the burden of proof is on you to demonstrate what that function is. If you claim that it must have a function, then, unless you can demonstrate that function, your hypothesis is falsified. And that includes the millions of copies of retroviruses, including the truncated ones, including the ones that cause disease and death and including the ones that demonstrate a hierarchical pattern that corresponds to the genetic similarities between organisms. As RIcky would say, you got a lot of spalin to do.

harold · 6 May 2011

Steve P. -

What is an example of something that is not intelligently designed? If you cannot answer this question you cannot honestly claim to "detect design". Lack of response (again) will be understood by all readers to constitute proof that you cannot respond.

eric · 6 May 2011

Robert Byers said: There were probably normal flying penguins and swimming/flying penguins.
A 9.5 for that sentence alone. I really couldn't ask for more from our resident cranks. Bravo sir, you have exceeded St. Augustine's wildest imaginings.

raven · 6 May 2011

Steve P the religious kook being stupid: Altair, you have that stuff in the drawer precisely because you know those things are ‘potentially’ useful.
This is very stupid. I'm sorry but the English language lacks the words for just how stupid it is, so "very" will have to fill in. This is a variant of the Front Loading Gibberish idea. The idea that the genome was created with a lot of genes and genetic programs 3.7 billion years ago that were designed to evolve in a preplanned way. Front Loading or Steve P.s toolkit and spare parts variant can't work. The mutation rate is too high. For DNA, it is use it or lose it. DNA that isn't being used very quickly becomes wrecked and eventually disappears. The mutation rate for any human is ca. 150/generation from their parents by actual counts. The amount of data on this would fill books. Two well known examples. 1. The antarctic ice fish are about 10 million years old. They have no red blood cells or hemoglobin because they live right at the freezing point of water. One globin gene has disappeared. The other is there but a barely visible fossilized wreck. 2. The human genome among its nonfunctional DNA has many thousands of retroviral sequences, relics of titantic battles in our past evolution. It is 5-8% of our genome, a huge number. None of them are any longer functional as retroviruses. (We did resurrect one, recreating life that was extinct for several million years.) Due to mutation rates, DNA that isn't being used gets scrambled in a few million years.

John Harshman · 6 May 2011

I don't know much about Steve P., but he's right about one thing: knockout experiments are a poor guide to junk DNA. Unless the knockout experiment is carried out in a large population over many generations, we can't tell if there was selective value in the bit that was eliminated. Small advantages whose absence doesn't show up as lethals or monsters can still become fixed in a population through selection. No, the better way to detect junk is over evolutionary time. Is it evolving at a neutral rate? That is, is it not conserved over millions of years? And we find that out by comparing sequences between species.

D. P. Robin · 6 May 2011

John Harshman said: I don't know much about Steve P., but he's right about one thing: knockout experiments are a poor guide to junk DNA. Unless the knockout experiment is carried out in a large population over many generations, we can't tell if there was selective value in the bit that was eliminated. Small advantages whose absence doesn't show up as lethals or monsters can still become fixed in a population through selection. No, the better way to detect junk is over evolutionary time. Is it evolving at a neutral rate? That is, is it not conserved over millions of years? And we find that out by comparing sequences between species.
William Paley crosses a heath and come across Steve P.'s arguments in a watch. He examine it and muses, "At least it is correct twice a day." dpr

harold · 6 May 2011

John Harshman said: I don't know much about Steve P., but he's right about one thing: knockout experiments are a poor guide to junk DNA. Unless the knockout experiment is carried out in a large population over many generations, we can't tell if there was selective value in the bit that was eliminated. Small advantages whose absence doesn't show up as lethals or monsters can still become fixed in a population through selection. No, the better way to detect junk is over evolutionary time. Is it evolving at a neutral rate? That is, is it not conserved over millions of years? And we find that out by comparing sequences between species.
Strongly agreed, I am sure by all non-creationists in the thread, that since much "junk" DNA shows no apparent selection constraints with regard to sequence or volume, we can clearly infer that these sequences have little impact on normal development and reproduction. In this sense, knockout experiments to prove this particular point are arguably superfluous. (The actual rationale for the mouse experiments is not merely to address this point.) (Humans also care about human phenotypic characteristics that might not have a strong selection impact in an obvious way. For example we care about health issues that occur overwhelmingly in post-menopausal women. So it remains conceivable that some types of "junk" DNA could have impacts that we care about. "Junk" DNA is a fairly diverse category.) Having said that, the fact that knockout mice lacking some "junk" DNA developed normally is still evidence that the particular DNA knocked out is somewhat problematic to ID/creationism. And that is the sole reason that Steve P. doesn't like it. To put it another way, ID/creationists will contradict any experiment with results that reinforce mainstream understanding of biology. Therefore many experiments and journal reports will simultaneously be critiqued by scientists, and condemned by creationists. But for more or less opposite reasons in most cases. Of interest, some ERV sequences seem to have an endosymbiotic function in placenta development (this is not a new idea - human ERVs can't function as reproductive viruses, but the DNA sequences still code for some mRNA and protein). If this continues to be verified then whatever ERV sequences are involved in this type of thing should not be thought of as "junk" (however, there are tens of thousands of ERVs in the human genome), if indeed anyone has ever categorized them as such. http://www.pnas.org/content/103/39/14390.

Sylvilagus · 6 May 2011

steve p. said: So its quite apt for what we know as non-coding DNA. It is at the ready for regulatory purposes and at the ready to be used for any new conditions that may arise that calls for modifications/alterations.
In other words ..... EVOLUTION.

Sylvilagus · 6 May 2011

Hey Steve - I posed some questions about your "design" detection claims down below on "This Week in ID". Sorry you never answered... where'd ya go? Still wanna play?

steve p. · 7 May 2011

This is very stupid. I’m sorry but the English language lacks the words for just how stupid it is, so “very” will have to fill in.
Shock value? Graffiti to dull the impact of an ID sympathetic post? What?
The mutation rate is too high. For DNA, it is use it or lose it. DNA that isn’t being used very quickly becomes wrecked and eventually disappears. The mutation rate for any human is ca. 150/generation from their parents by actual counts.
Wait! No. OK, I see. DNA that isn't being used gets wrecked and eventually disappears. Soooo. That means all the non-coding DNA which we have in our genome but has not yet been found to have function must nonetheless still have potential function; simply undiscovered to date. After all, it is still in the genome and has not disappeared. So we can presume that some DNA got wrecked for whatever reason BUT because it is still present in the genome, has found or will find a new job to do; you know, not for reproduction, but for regulation, or some such other boring task. That means life is resourceful against pressure, adversity; turns lead into gold. I can deal with that. I think I will start studying alchemy.

steve p. · 7 May 2011

If you want to claim that all “junk” DNA has a function, the burden of proof is on you to demonstrate what that function is. If you claim that it must have a function, then, unless you can demonstrate that function, your hypothesis is falsified. And that includes the millions of copies of retroviruses, including the truncated ones, including the ones that cause disease and death and including the ones that demonstrate a hierarchical pattern that corresponds to the genetic similarities between organisms. As RIcky would say, you got a lot of spalin to do.
No I don't want to claim ALL junk DNA has function. What is at issue is why would anyone make the original claim that non-coding DNA / junk DNA is largely useless or non-functional. How does a scientist arrive at such a conclusion? Out-of-sight-is-out-of-mind is a poor conceptual framework for dealing with the issue. From a logical point of view, Raven's view seems correct. Use it or lose it. So the genome is using it. We just don't know all the details of just how it is being used. That is the exciting part of science, no? Scary to some heavily invested philosophical interests, true. But from a scientific POV, discovering layered, hierarchical patterns of command and control of the genome, is well, er not all that stupid of an idea. We know it happens in the nano machinery of life, ie flagellum, etc. So looks like non-coding DNA and DNA segments are prime candidates for the role of commanding, controlling, regulating, and monitoring the genome as a whole. The patterns are elusive but thats where ID will come in: Man reflects on his own work to discover the genome operates with the same concepts.

Mike Haubrich · 7 May 2011

I was hoping that it would be in some sort of format that would allow me to view it with an opensource video player,

John Harshman · 7 May 2011

steve p. said: Wait! No. OK, I see. DNA that isn't being used gets wrecked and eventually disappears. Soooo. That means all the non-coding DNA which we have in our genome but has not yet been found to have function must nonetheless still have potential function; simply undiscovered to date. After all, it is still in the genome and has not disappeared. So we can presume that some DNA got wrecked for whatever reason BUT because it is still present in the genome, has found or will find a new job to do; you know, not for reproduction, but for regulation, or some such other boring task.
No, we can't presume any such thing. Junk DNA doesn't disappear fast enough for you to conclude that anything that's still here is functional. It's better to examine that process of "wrecking". DNA that does something is under selection. Many mutations that happen to DNA under selection are deleterious, and so the sequence changes at less than the rate of mutation. If you see a sequence that's changing at the rate of mutation, it's evolving neutrally, and so can be supposed to have no function. Most of the genome, and most of the non-coding DNA, is evolving in that way and is therefore probably junk. Almost all the protein-coding DNA and some of the non-coding DNA is evolving much more slowly than the neutral rate and is therefore probably not junk. We can tell the evolutionary rate by comparing sequences in different species. For example, we can tell what's junk in humans by comparing with the corresponding sequences in chimps. Neutrally evolving sequences have accumulated an average of 1.3 changes per 100 bases, and also get more frequent indels. Non-junk has changed on average much less.

harold · 7 May 2011

Steve P. -
We know it happens in the nano machinery of life, ie flagellum, etc. So looks like non-coding DNA and DNA segments are prime candidates for the role of commanding, controlling, regulating, and monitoring the genome as a whole.
On the contrary, this is the opposite of what the evidence suggests, and the reasons why have been explained on this thread. 1) Changes in the sequence of most of what is called "junk" DNA aren't selected against; see John Harshman's comments above. In fact, as has been noted repeatedly in this thread, this is exactly why such sequences are good for determining genealogical relationships. 2) The volume amount of "junk" in the genomes of highly similar species, or indeed, even individuals within the same species, can vary massively. 3) Since the term "junk" is, yes, it is, rather imprecise (more precise than "non-coding" but still imprecise), and since it applies to a large amount of diverse types of DNA sequences within most eukaryotic genomes, no-one has ever made the argument that no type of DNA that has ever been called "junk" by anyone cannot ever have an impact on phenotype. Within the constraints of the facts noted above in "1)" and "2)". 4) Once again, creationists are trying to set up a straw man and then declare victory by arguing against something that no-one ever said, anyway. 5) You claim to be interested in "junk" DNA, but I think you're lying and are completely ignorant of it. Prove me wrong by posting a summary, in your own words, of what is currently known about the various components of "junk" DNA. 6) What is an example of something that is not "intelligently designed"?

harold · 7 May 2011

That means life is resourceful against pressure, adversity
Because it evolves.

raven · 7 May 2011

steve P. lying: steve p. said: Wait! No. OK, I see. DNA that isn’t being used gets wrecked and eventually disappears.
I see Steve P. has resorted to his standby. Lying. Creationism is a lie and all creationists are liars. I didn't say that DNA not being used disappears. It can but more often it gets scrambled and wrecked. Noncoding and nonfunctional DNA can also appear or accumulate. One of the most common mutational differences between any two people are indels. Indels stands for insertions and deletions. DNA can end up deleted. It can also end up inserted. In the real world, the amount of nonfunctional DNA in a genome is in rough equilibrium between being deleted and being accumulated. There are almost 1/2 million INDEL polymorphisms in humans, about equal numbers of insertions and deletions.
Genome Res. 2006 September; 16(9): 1182–1190. doi: 10.1101/gr.4565806. PMCID: PMC1557762 An initial map of insertion and deletion (INDEL) variation in the human genome Ryan E. Mills,1,2 Christopher T. Luttig,1 Christine E. Larkins,3 Adam Beauchamp,4 Circe Tsui,1,2 W. Stephen Pittard,2,5 and Scott E. Devine1,2,3,4,6 1Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322, USA; 2Center for Bioinformatics, Emory University School of Medicine, Atlanta, Georgia 30322, USA; 3Biochemistry, Cell, and Developmental Biology Graduate Program, Emory University School of Medicine, Atlanta, Georgia 30322, USA; 4Genetics and Molecular Biology Graduate Program, Emory University School of Medicine, Atlanta, Georgia 30322, USA; 5Bimcore, Emory University School of Medicine, Atlanta, Georgia 30322, USA 6Corresponding author. Received August 13, 2005; Accepted July 12, 2006. This article has been cited by other articles in PMC. Other Sections▼Abstract Although many studies have been conducted to identify single nucleotide polymorphisms (SNPs) in humans, few studies have been conducted to identify alternative forms of natural genetic variation, such as insertion and deletion (INDEL) polymorphisms. In this report, we describe an initial map of human INDEL variation that contains 415,436 unique INDEL polymorphisms. These INDELs were identified with a computational approach using DNA re-sequencing traces that originally were generated for SNP discovery projects. They range from 1 bp to 9989 bp in length and are split almost equally between insertions and deletions, relative to the chimpanzee genome sequence. Five major classes of INDELs were identified, including (1) insertions and deletions of single-base pairs, (2) monomeric base pair expansions, (3) multi-base pair expansions of 2–15 bp repeat units, (4) transposon insertions, and (5) INDELs containing random DNA sequences. Our INDELs are distributed throughout the human genome with an average density of one INDEL per 7.2 kb of DNA. Variation hotspots were identified with up to 48-fold regional increases in INDEL and/or SNP variation compared with the chromosomal averages for the same chromosomes. Over 148,000 INDELs (35.7%) were identified within known genes, and 5542 of these INDELs were located in the promoters and exons of genes, where gene function would be expected to be influenced the greatest. All INDELs in this study have been deposited into dbSNP and have been integrated into maps of human genetic variation that are available to the research community.

RWard · 7 May 2011

SteveP, I think you need some help. There are persuasive arguments you've failed to employ. For instance, why not argue that 'junk' DNA is just information that the Designer front-loaded in full knowledge that someday the information in those sequences will be needed. The Designer, in His infinite wisdom, has provided man, His penultimate creation, with the genetic resources needed to experience the rapture (21 May 2011, by the way). Embedded in those dinucleotide repeats, Alu elements, and pseudogenes are the codes we will need to open the pearly gates.

God bless you little man.

raven · 7 May 2011

SteveP, I think you need some help. There are persuasive arguments you’ve failed to employ.
Next up. God's spare parts and junk drawer has a hole in it. Stuff keeps disappearing. So he keep filling it up with retroviral sequences, insertion sequences, and gene duplications. God has always been a pretty kludgy tinkerer. He could just find the holes and fill them in.

Just Bob · 7 May 2011

raven said: God has always been a pretty kludgy tinkerer. He could just find the holes and fill them in.
God is VERY limited in his abilities. Read ANY part of the Old Testament.

sylvilagus · 8 May 2011

steve p. said: No I don't want to claim ALL junk DNA has function. What is at issue is why would anyone make the original claim that non-coding DNA / junk DNA is largely useless or non-functional. How does a scientist arrive at such a conclusion?
This has been explained to you numerous times on this thread. You just keep ignoring it. And my questions. And the questions of others. Are you actually interested in or capable of real discussion and learning? Others here keep saying you aren't. You're starting to convince me too, and the other lurkers.

Just Bob · 8 May 2011

"How does a scientist arrive at such a conclusion?"

By, you know, doing SCIENCE. And having it checked over multiple times by others who would just love to blow the original conclusion out of the water.

Now, how do creationists arrive at their conclusions?

(Answer: They don't have to. The "conclusions" are handed down from scripture, pastors, "bible study" groups, etc. They're really PREclusions. Saves a lot of work.)

Stanton · 8 May 2011

Just Bob said: "How does a scientist arrive at such a conclusion?" By, you know, doing SCIENCE. And having it checked over multiple times by others who would just love to blow the original conclusion out of the water. Now, how do creationists arrive at their conclusions? (Answer: They don't have to. The "conclusions" are handed down from scripture, pastors, "bible study" groups, etc. They're really PREclusions. Saves a lot of work.)
And yet, creationists remained dumbfounded and agonized over why scientists refuse to take them or their preclusions seriously.

hoary puccoon · 8 May 2011

Stanton said: ....creationists remained dumbfounded and agonized over why scientists refuse to take them or their preclusions seriously.
Maybe the rank and file are dumbfounded. But I'm betting Ken Ham, Dembski, et. al., know perfectly well they're pulling a scam. I don't believe they *want* scientists to take them seriously. It would interfere with their playing the martyr and pulling in the contributions of the faithful.

steve p. · 10 May 2011

I didn’t say that DNA not being used disappears. It can but more often it gets scrambled and wrecked.
Raven said quote, unquote on this thread on 5/6/2011 at 9:59 a.m.:
The mutation rate is too high. For DNA, it is use it or lose it. DNA that isn’t being used very quickly becomes wrecked and eventually disappears. The mutation rate for any human is ca. 150/generation from their parents by actual counts.
Accusing someone of lying is not the sharpest tool to have in ur rhetorical bag, Raven. The glaring point is no one knows just what all that so-called junk DNA is doing in the genome. But without doubt the current trend is for finding function. So the only scientific and logical thing to do is keep looking for MORE function. That's IMO where the revolutionary breakthroughs in our knowledge of how life is constructed and regulated will come from. And design detection will be there to make sense of the multiple layers of command and control that are at present elusive because they are natural but not material in nature. That's the point you (pl) keep missing. Take off those philosophical ray-bans for a change.

steve p. · 10 May 2011

Just Bob said: "How does a scientist arrive at such a conclusion?" By, you know, doing SCIENCE. And having it checked over multiple times by others who would just love to blow the original conclusion out of the water. Now, how do creationists arrive at their conclusions? (Answer: They don't have to. The "conclusions" are handed down from scripture, pastors, "bible study" groups, etc. They're really PREclusions. Saves a lot of work.)
when's the last time you cyber-heard me talking about the bible and scripture. 'nuff said.

DS · 10 May 2011

Steve wrote:

"But without doubt the current trend is for finding function. So the only scientific and logical thing to do is keep looking for MORE function. That’s IMO where the revolutionary breakthroughs in our knowledge of how life is constructed and regulated will come from."

So why aren't you doing this? Why aren't you looking for functions for all of the junk DNA? Why won't you admit that some has no function whatsoever that has ever been found? Why can't you admit that some DNA evolves at a rate consistent with the hypothesis that it is under no functional constraint? Why can't you admit that the people who have actually studied the genome and have earned the right to an opinion have all concluded that it is is exactly what one would expect if it were the product of random mutation and natural selection?

"And design detection will be there to make sense of the multiple layers of command and control that are at present elusive because they are natural but not material in nature. That’s the point you (pl) keep missing."

So why can't you do this? What are you waiting for? Why don't you tell everyone how "design detection" can explain endogenous retroviruses and their hierarchical insertion pattern? Why don't you explain exactly what is "not material in nature", exactly how it works and why?

"Take off those philosophical ray-bans for a change."

Typical projection from someone who sees the world through the lens of ignorance.

harold · 10 May 2011

Steve P. - Whether or not someone who repeats crap is a "liar" is a philosophical question. Is intent to deceive required? Can we infer intent to deceive over the internet? Who can say? I leave it to the philosophers and experts in semantics to determine whether or not you should be called a "liar". But you certainly repeat crap that has already been addressed.
The glaring point is no one knows just what all that so-called junk DNA is doing in the genome.
There is some truth to this statement if interpreted generously. However, as I have stated multiple times, we DO know where much of it came from, and how much of it reproduces itself. No magic required. http://en.wikipedia.org/wiki/Endogenous_retrovirus http://en.wikipedia.org/wiki/Retrotransposon http://en.wikipedia.org/wiki/Transposable_elements
But without doubt the current trend is for finding function.
Again, some truth if the imprecise statement is interpreted generously. I strongly prefer a term like "effect", rather than the loaded term "function". As you have been told multiple times now without once having the decency to acknowledge that you have been told, "junk" DNA elements tend not to be sequence or volume constrained by selection in many organisms. Very similar organisms can have massively different amounts of "junk" DNA. Therefore, we can infer that these sequences do not have "function" in the same way that alleles do. Now we run into some of the shit that rightfully causes people to have a very negative opinion or you.
So the only scientific and logical thing to do is keep looking for MORE function. That’s IMO where the revolutionary breakthroughs in our knowledge of how life is constructed and regulated will come from. And design detection will be there to make sense of the multiple layers of command and control that are at present elusive because they are natural but not material in nature. That’s the point you (pl) keep missing.
Really? Okay - show me how to detect design. You're the one who wants design to be detected. Show me how. Let's start with an easy step. What is an example of something that isn't designed? That's all I'm asking for right now. The example. We can discuss how you knew it wasn't designed after you pick the example. What is an example of something that isn't designed? What is an example of something that isn't designed? What is an example of something that isn't designed? What is an example of something that isn't designed? What is an example of something that isn't designed? What is an example of something that isn't designed? What is an example of something that isn't designed? What is an example of something that isn't designed? Take off those philosophical ray-bans for a change.

steve p. · 11 May 2011

Harold et al,

You(pl) don't need me to tell you the answer to the question "What is not designed?" You have already answered it by utilizing design parameters a a guide.

Not so subtle hint: random mutation.

How do you know those mutations are random? What are u using as a comparative tool? You must have some idea of what is NOT a random mutation? What template are you using to chock up a match? You do have a pattern in mind, I presume.

Your moment of Zen.

Dale Husband · 11 May 2011

steve p. said: Not so subtle hint: random mutation. How do you know those mutations are random? What are u using as a comparative tool? You must have some idea of what is NOT a random mutation? What template are you using to chock up a match? You do have a pattern in mind, I presume. Your moment of Zen.
Because most mutations are harmful and many are neutral, you idiot. If mutations were not random, we should be able to find a non-random mechanism to cause them, but there is none. The causes we are aware of (chemical changes, radiation, non disjunction) have random effects, so we have no reason to think they are not random or that there is a non-random cause at all for mutations. Got any other dumb questions?

harold · 11 May 2011

Steve P. -
You(pl) don’t need me to tell you the answer to the question “What is not designed?” You have already answered it by utilizing design parameters a a guide. Not so subtle hint: random mutation. How do you know those mutations are random? What are u using as a comparative tool? You must have some idea of what is NOT a random mutation? What template are you using to chock up a match? You do have a pattern in mind, I presume.
You are the one who is claiming that mutations are the result of "design". A "random variable" is just something that happens, where I can predict the frequency of certain outcomes over time, but can't predict the exact outcome of each individual event. http://en.wikipedia.org/wiki/Random_variable Mutations are random. "Random" is not the opposite of "designed". I also have no reason to think that mutations are designed. They are chemical reactions and follow the same principles of chemistry and physics as other chemical reactions. This would be true whether or not they are "random". "Random" merely refers to how precisely they can be predicted by a human observer. You want to tell me they are "designed". Fine, I am willing to listen. But first you have to tell me how to "detect design". And you obviously can't. The obvious first step would be to at least agree on something that YOU agree isn't designed. What is an example of something that YOU agree isn't designed? Your moment of Zen.

DS · 11 May 2011

steve p. said: Harold et al, You(pl) don't need me to tell you the answer to the question "What is not designed?" You have already answered it by utilizing design parameters a a guide. Not so subtle hint: random mutation. How do you know those mutations are random? What are u using as a comparative tool? You must have some idea of what is NOT a random mutation? What template are you using to chock up a match? You do have a pattern in mind, I presume. Your moment of Zen.
Dead wrong again Steve. Mutations are indeed random in a very specific way. If you disagree, the burden of proof is non you to demonstrate that they are not, how they are not and why they are not. There is a vast literature on this. I can provide you with over a thousand references, if you promise to read them. If not, then STFU and go away. No one is fooled by your hollow blustering and your foolish displays of ignorance. No one cares what you believe.

harold · 11 May 2011

In the past, Steve P. has demonstrated that he can't state who the designer is, what the designer did, how the designer did it, or when the designer did it.

In this thread, he shows that he can't even discuss how to tell whether something is "designed" or not.

Wolfhound · 11 May 2011

harold said: In the past, Steve P. has demonstrated that he can't state who the designer is, what the designer did, how the designer did it, or when the designer did it. In this thread, he shows that he can't even discuss how to tell whether something is "designed" or not.
Well, he "can't" in the sense that if he stated What or Who actually designed stuff and how What or Who did it, he'd blow his "I'm not really religiously motivated, I just want TEH TROOF" schtick. Why do these goofballs think they're clever?

Henry J · 11 May 2011

"Designed" is the wrong word, anyway. To determine if something was deliberately made the way it is, look for signs of [i]engineering[/i], not for signs of "design".

That's just my 2 cents.

steve p. · 11 May 2011

You guys are really full of shit. Dale here says most mutations are harmful and many are neutral. But are they when bacteria mutate to create resistance to antibiotics? Is the bacteria just so f@#kin' lucky to get a get-out-of-jail card?

NO! It actively seeks a mutation that will fit the bill. When it does, it prevents its own annihilation. Luck-o-the-draw, you say? Emergent property, you say? Whatever it is, it ain't design, you say? Ookaaaayyyy.

Mutations caused by environmental factors like radiation ARE random AND non-designed. BUT the genome actively repairing what it can of the damage done IS clearly design.

So here, in two examples, we can clearly differentiate what mutations are non-designed and which ones are by design. Simple and straight forward, any kid'll pick it up in a heart beat.

Now try and tell 'em how it is not design but 'emergent phenomena'. Like I said you guys have a major, major marketing problem. I mean shit, your explanations are so convoluted and contradictory, you have to actually go around selling your position door-to-door.

Here's a glaring example of the problem with your thinking. Elzinga says there is no dichotomy between life and non-life. You guys say there is no dichotomy between macro and micro-evolution.

Yet, you assert a dichotomy exists between Man designing in particular and non-design of nature in general. And to assert that dichotomy, you must reject and deny all the evidence for design that we ACTUALLY FRIGGIN' OBSERVE under the microscope.

You have to painstakingly remind everyone over and over again that what they see MAY appear as design but REALLY its not; the genome may appear to be 'searching, and repairing, and finding, and sorting, and controlling, and commanding, and talking, and making collective decisions BUT, those are just words don't forget. What you see is not what is.

Not only that, you have to borrow as much design language and imagery as you can to make it go down better.

Who's kiddin' who here?

mrg · 11 May 2011

Oh, how tired.

DS · 11 May 2011

Steve,

SO, you admit that mutations are random. Good, now we are getting somewhere. No one claimed that which mutations are repaired is not random. No one claimed that which mutations survive is not random.

You have demonstrated how random mutation and natural selection can produce things that appear to be designed but actually are not. The illusion of design does not mean that design is real.

Bacteria "actively seek mutations that fit the bill"? Really? How exactly do they do this? Why do they do this? By what mechanism do they do this? What happens to all of those random mutations that happen to them anyway? Why is there absolutely no evidence of this? Why have you provided no references to the scientific literature? Could it be you re just making crap up? Could it be that you are emotionally incapable of admitting that there is no evidence whatsoever for any design in nature?

You have absolutely and utterly failed to describe any mechanism whatsoever by which nonrandom mutations could possibly be produced. You have failed to describe the goal of such nonrandom mutations. In short, you have failed miserably once again. Thanks for playing.

eric · 11 May 2011

steve p. said: Dale here says most mutations are harmful and many are neutral. But are they when bacteria mutate to create resistance to antibiotics?
Obviously if "most" are harmful and neutral, that implies that there's some that are neither. I.e. there are some that are positive.
Is the bacteria just so f@#kin' lucky to get a get-out-of-jail card?
In a word, yes. Wondering how a resistant bacteria can arise in a generation is sort of like wondering how there can be a lottery winner almost every week. You have a lot of bacteria playing the bacterial resistance lottery here. A lot more than you would need to have a reasonable chance of seeing a winner. As Behe had it pointed out to him in Dover, there's 10^16 critters in every ton of soil. This was 7 orders of magnitude more than what he calculated was needed for the evolution of a new trait requiring two individual mutations.
BUT the genome actively repairing what it can of the damage done IS clearly design.
Asserting it with capital letters isn't proof. If DNA repair mechanisms were designed, show us the designer. Show us evidence of the design event. Where is the designer's lab? Where are his tools? If it's one designer doing all the critters, why do some critters have less good repair mechanisms than others? Why not just take the mechanisms he used in the most radiation resistant organisms and plunk those into all his other designs? That is what a good designer would do.
I mean shit, your explanations are so convoluted and contradictory, you have to actually go around selling your position door-to-door.
There's nothing convoluted about this. The number of bacteria vastly exceed the the fractional odds of any particular resistance occurring. So resistance evolves quite regularly. And I'm not using some "evilutionist's" caculations when I make that statement, I'm using Behe's.

Science Avenger · 11 May 2011

steve p. said: ...to assert that dichotomy, you must reject and deny all the evidence for design that we ACTUALLY FRIGGIN' OBSERVE under the microscope.
But we don't observe evidence of design. We don't observe borrowing of ideas across lineages, we don't observe foresight, we don't observe increased simplicity, we don't see the discarding of obselete parts, and we sure as shit haven't observed any blueprints. You guys have only one drum, complexity implies design, and you've pounded it so hard and so long you've become blind to how obviously wrong it is. Complexity does NOT imply design. Simplicity is a far better indicator.
You have to painstakingly remind everyone over and over again that what they see MAY appear as design but REALLY its not; the genome may appear to be 'searching, and repairing, and finding, and sorting, and controlling, and commanding, and talking, and making collective decisions BUT, those are just words don't forget. What you see is not what is.
No, your INTERPRETATION of what you see is not what it is. That's the real religion for people like you Steve. I've met a thousand of you in my previous forays into alternative medicine. You can be skeptical of any issue save one: your ability to accurately interpret your experience. THAT is your holy grail never to be questioned. Hell, most of you can't seem to get a real handle on the difference between the intepretation and the experience. It's all one and the same to you. Well it isn't, and your interpretation is wrong, and all the little temper tantrums you can throw won't change that. Grow up.

fnxtr · 11 May 2011

"marketing strategy"? "Selling door-to-door"? "language and imagery"? Holy shit, Steve. Talk about a man with an axe. Maybe you should take some time off work.

you must reject and deny all the evidence for design that we ACTUALLY FRIGGIN’ OBSERVE under the microscope.

Really? Such as what? Really, Steve, I want to know. What evidence, besides "Gee, that sure looks complicated", or "hey, that looks like something I'd make"? (See, all other examples of "intelligent design" are actually examples of human design, (unless you're Joe G, in which case termites are intelligent) so it makes as much sense to argue that people (or termites) invented life.) Point to the mutation, the indel, the duplication, and show me how god, sorry, an unnamed designer did his/her work. Targeted x-rays? Manipulation of the gravitational constant? Rare earth magnets? Pyramid power? And whose "we"? When's the last time you did anything even remotely related to biological research? (headdesk/facepalm)

mrg · 11 May 2011

eric said: There's nothing convoluted about this.
And if it could be argued that it is, so what? If evo science is complicated and sounds crazy, it's nothing compared to quantum physics. Nobody's particularly happy with quantum physics, most would prefer something cleaner, but they just don't have any real alternative: "Professor Feynman, I don't believe that!" "Well, go do the experiments until you DO believe it!" It seems a strange sort of complaint to say that one's science classes are hard to follow, this being more a relevant observation on the student than on the subject under study.

fnxtr · 11 May 2011

ei*pi-1=0 is the one that really fucked me up.

DS · 11 May 2011

Steve wrote:

"Dale here says most mutations are harmful and many are neutral. But are they when bacteria mutate to create resistance to antibiotics?"

Dale is right. And that's exactly what you would expect if mutations are random. It is absolutely NOT what you expect if they are designed. It is also exactly what we observe in nature and in laboratory experiments.

Take the Lenski experiment for example. You do know about that experiment don't you Steve? I can provide the reference for you, if you promise to read it. It demonstrates exactly what is expected from random mutations and natural selection. That is the conclusion drawn by the author, you know, the one who actually performed the experiment. Now you can yell and scream all you want, but the evidence contradicts your meaningless bluster. So do all of the experiments regarding the evolution of antibiotic resistance. Once again, I can provide references, can you?

"…to assert that dichotomy, you must reject and deny all the evidence for design that we ACTUALLY FRIGGIN’ OBSERVE under the microscope."

Except you have never actually looked under a microscope have you Steve? And you have never actually observed any design have you Steve (and neither has anyone else)? And you refuse to believe those who have actually looked under microscopes don't you Steve? (By the way, looking UNDER the microscope doesn't really work. You have to look through the lens). See Steve, here is the thing. as has been repeatedly pointed out to you, looking at something and claiming it must have been designed is NOT evidence. If you think that it is, then I can just as easily look at something and say it wasn't designed. Of course, I can back up my claims, you on the other hand, obviously cannot.

harold · 11 May 2011

steve p. said:
You guys are really full of shit. Dale here says most mutations are harmful and many are neutral. But are they when bacteria mutate to create resistance to antibiotics? Is the bacteria just so f@#kin' lucky to get a get-out-of-jail card?
Of course. Otherwise, why do antibiotics ever work? If resistance to antibiotics is magically designed to help bacteria, why are so many bacteria killed by antibiotics? Neither "most" nor "many" means "all". (Incidentally, "most" have no effect.)
NO! It actively seeks a mutation that will fit the bill. When it does, it prevents its own annihilation. Luck-o-the-draw, you say? Emergent property, you say? Whatever it is, it ain't design, you say? Ookaaaayyyy.
How does a bacterium "actively seek a mutation"? It's obvious how an allele that confers antibiotic resistance, due to a random mutation at some point in the past, will be selected for when antibiotics are applied to a population. You don't deny that do you? That's easy to understand. But how does a bacterium "actively seek a mutation"? Also, why does the designer sometimes favor humans by killing bacteria with antibiotics, and sometimes favor bacteria, by making them resistant to some antibiotics? (For completeness, antibiotic resistance is sometimes passed on by horizontal gene transfer and sometimes due to chromosome mutations http://en.wikipedia.org/wiki/Antibiotic_resistance)
Mutations caused by environmental factors like radiation ARE random AND non-designed.
How do you explain that fact that beneficial mutations may arise this way?
BUT the genome actively repairing what it can of the damage done IS clearly design.
Great, here is a testable prediction. DNA repair mechanisms are well understood and natural. Unless I misunderstand, your claim here is that DNA repair mechanisms will repair harmful mutations but not beneficial mutations. You'll have to be a little more specific. We'll need to define what we can both accept as beneficial mutation, for example. You'll also have to explain why there are any harmful mutations. Still, I propose a test. Clearly, if DNA repair mechanisms operate on the basis of something other than whether or not a mutation is beneficial, your claim here would be wrong. Do you agree? Would you like to do this test? Will you concede, if it turns out that DNA repair mechanisms operate on some other basis, that you were wrong?
So here, in two examples, we can clearly differentiate what mutations are non-designed and which ones are by design. Simple and straight forward, any kid'll pick it up in a heart beat.
Sorry, I still don't entirely understand. Are you saying that beneficial mutations are designed but harmful mutations are not designed? Can you say that in a more direct and straightforward manner, if that is your claim? What about neutral mutations?
Now try and tell 'em how it is not design but 'emergent phenomena'. Like I said you guys have a major, major marketing problem. I mean shit, your explanations are so convoluted and contradictory, you have to actually go around selling your position door-to-door. Here's a glaring example of the problem with your thinking. Elzinga says there is no dichotomy between life and non-life. You guys say there is no dichotomy between macro and micro-evolution. Yet, you assert a dichotomy exists between Man designing in particular and non-design of nature in general. And to assert that dichotomy, you must reject and deny all the evidence for design that we ACTUALLY FRIGGIN' OBSERVE under the microscope. You have to painstakingly remind everyone over and over again that what they see MAY appear as design but REALLY its not; the genome may appear to be 'searching, and repairing, and finding, and sorting, and controlling, and commanding, and talking, and making collective decisions BUT, those are just words don't forget. What you see is not what is. Not only that, you have to borrow as much design language and imagery as you can to make it go down better.
Don't you think that random generation of variability, followed by environmental selection, would indeed produce these impressions? Who's kiddin' who here? There are still questions I'd like to see answered. 1) What is an example of something that is not designed? You seem to be saying that at least some mutations are not designed. As I requested above, can you clarify? Are only harmful mutations not designed? What about neutral mutations? What about cases where the cause of the mutation clearly is a natural process, yet it is beneficial anyway? 2) Who is the designer, what does the designer do, when does the designer do it, and how does the designer do it?

Stanton · 11 May 2011

So Steve P.'s definition of "designed" is beneficial, and "not designed" is harmful...

And he thinks we're full of shit?

DS · 11 May 2011

Of course. Isn't it obvious. Random can't mean beneficial and designed can't mean deleterious. That would be crazy. Makes perfect sense to me. Of course, the evidence still is completely against this, but who cares? This is what Steve wants to believe so it must be true. And if he screams it loud enough and often enough, it must then be true. Too bad he can't explain the actual evidence. But then again, how could he if he has never looked "under" a microscope or read a paper by anyone who actually has?

Henry J · 11 May 2011

Random can’t mean beneficial

Random in general means scattered among a set of possible results. If one or more of the possibilities are beneficial, and if the number of reproductive events is much larger than the size of that set, then some of the beneficial results will occur occasionally. (Though not necessarily the one a researcher happens to be looking for at the moment.)

and designed can’t mean deleterious.

Heck, designed means whatever the designing entity wants it to mean.

Just Bob · 11 May 2011

steve p. said: I mean shit...
Thanks for clarifying.

Mike Elzinga · 11 May 2011

Stanton said: So Steve P.'s definition of "designed" is beneficial, and "not designed" is harmful... And he thinks we're full of shit?
The averaging of random phenomena can usually pull out subtle underlying patterns. And it might require millions upon millions of samples to get there. So far, no pattern seems to be emerging from Steve P's random walks. But we haven't had billions of samples yet. So far, it appears to be just noise.

mrg · 11 May 2011

Mike Elzinga said: The averaging of random phenomena can usually pull out subtle underlying patterns. And it might require millions upon millions of samples to get there.
As an example, radioactive half-life curves that can calculated down to three signficant figures at the very worst, despite the fact that there is absolutely no way to predict the decay time of an individual atom.
But we haven't had billions of samples yet. So far, it appears to be just noise.
Hopefully, a decay halflife will emerge.

Henry J · 11 May 2011

But is that half-life constant over time?

eric · 11 May 2011

Henry J said: But is that half-life constant over time?
For every earth-based empirical measurement, yes. For every astronomical measurement, which includes observations of the behavior of objects millions of light-years away (think about it), yes. And the fundamental physical theory on which half-life is based also predicts yes. Any other questions?

Henry J · 11 May 2011

Not that half-life! :p

fnxtr · 13 May 2011

You gotta wonder why Steve Pee continues his drive-bys. He's like the dopey kid in the "Pretty Fly For a White Guy" video who thinks he's hip.

mrg · 13 May 2011

fnxtr said: You gotta wonder why Steve Pee continues his drive-bys.
Because that is the best he can do. Since he can't do a good job and win praise, he does a schlock job to pick fights.

Alan B · 13 May 2011

The next stage of penguin evolution?

http://www.youtube.com/watch?v=9dfWzp7rYR4

(Sorry if this has already been cited but 134 comments is a lot to go through!)

fnxtr · 13 May 2011

Some fine cinematography there.

Steve Martin explained that word at the Oscars one year: "Cinema, from the Greek word, meaning film, and... tography..."
(blinks, wanders off confused)

Just Bob · 13 May 2011

Henry J said:

and designed can’t mean deleterious.

Heck, designed means whatever the designing entity wants it to mean.
And Stevie is begging the question. He assumes that the "designer" is perfectly competent. All the designers I know anything about are perfectly capable of screwing up big time (think Edsel, or Chernobyl). Of course Stevie's designer isn't the xian god (wink, wink), but even he is hardly infallible. Try counting how many times he screwed up in Genesis alone.

steve p. · 16 May 2011

DS said: Steve, SO, you admit that mutations are random. Good, now we are getting somewhere. No one claimed that which mutations are repaired is not random. No one claimed that which mutations survive is not random. You have demonstrated how random mutation and natural selection can produce things that appear to be designed but actually are not. The illusion of design does not mean that design is real. Bacteria "actively seek mutations that fit the bill"? Really? How exactly do they do this? Why do they do this? By what mechanism do they do this? What happens to all of those random mutations that happen to them anyway? Why is there absolutely no evidence of this? Why have you provided no references to the scientific literature? Could it be you re just making crap up? Could it be that you are emotionally incapable of admitting that there is no evidence whatsoever for any design in nature? You have absolutely and utterly failed to describe any mechanism whatsoever by which nonrandom mutations could possibly be produced. You have failed to describe the goal of such nonrandom mutations. In short, you have failed miserably once again. Thanks for playing.
Same 'o schtick from you DS. FYI, bacteria are known to coordinate an attack on their host. They multiply but do not infect the host until a threshold number has been reached. The stay in contact to signal their numerical condition. When the target number is reached, communication/signalling increases, and subsequently the invasion of the host begins. Tell me, DS? How do these bacteria communicate? How are they able to calculate their own numbers? How do they signal a command? Which one(s) do the signalling? Do we need answers to them to understand what is happening? No, we want them to be sure. But the absence of answers to the details does not prevent us from recognizing that in fact they are doing just that, communicating, calculating, deciding, responding, etc. So how is the converse not possible? When a population of bacteria are attached by anti-biotics, there is no alarm sounded? No communication? No signalling? No commands? No relaying of information? A good intuition will lead to answers to the above questions. However, premature rejection/denial of the possibility/probability is (to put it mildly)imprudent and unjustified in light of the findings regarding bacterial invasion behavior. IOW, your refusal to follow the evidence where it leads hinders YOUR ability to understand what is actually happening. We are not the only smart cookies on the planet. Even 'lil bitty 'isms like bacteria possess intelligence. Remarkable intelligence. Since when did you believe that only organisms with brain stems and a cerebrum have dibbs on intelligence. Your philosophy is more of a hinderance than a vehicle.

steve p. · 16 May 2011

Wolfhound said:
harold said: In the past, Steve P. has demonstrated that he can't state who the designer is, what the designer did, how the designer did it, or when the designer did it. In this thread, he shows that he can't even discuss how to tell whether something is "designed" or not.
Well, he "can't" in the sense that if he stated What or Who actually designed stuff and how What or Who did it, he'd blow his "I'm not really religiously motivated, I just want TEH TROOF" schtick. Why do these goofballs think they're clever?
Wolfhound gets her two-bit sound-bite in. Clap for the wolfma... er wolfhound.

Stanton · 16 May 2011

Steve P, if you have ever bothered to read a book on Microbiology, you wouldn't need to make your colossally stupid, yet pathetically impassioned plea to ignorance.

I mean, honestly, are you saying that pathogenic bacteria are sentient? Don't tell me that you're stupid enough to think cartoons like Osmosis Jones are documentaries.

If there really is some sort of intelligence coordinating the efforts of pathogenic bacteria, why hasn't this intelligence made any effort to communicate with humans?

Why would actual bacteriologists, who have spent literal lifetimes studying bacteria, have seen absolutely no trace of this alleged intelligence, while, only you, Steve P, a pompous fabric salesman who prides himself on his crippling science illiteracy, would be able to see the evidence?

steve p. · 16 May 2011

But we don’t observe evidence of design. We don’t observe borrowing of ideas across lineages, we don’t observe foresight, we don’t observe increased simplicity, we don’t see the discarding of obselete parts, and we sure as shit haven’t observed any blueprints. You guys have only one drum, complexity implies design, and you’ve pounded it so hard and so long you’ve become blind to how obviously wrong it is. Complexity does NOT imply design. Simplicity is a far better indicator.
SA, denying design in nature is like denying yourself. We do observe foresight -repair means a genome knows it needs to make an adjustment or die. It may not know in the way humans know, but nevertheless it must know. Otherwise, it couldn't act on a mistake and correct it. To reject this is to outright reject basic logic. Happens alot here. True, we haven't observed blueprints because they are not material but natural nonetheless. that is what is exciting about design. Some smart scientist will inevitably come along to demonstrate the characteristics of biological blueprints the way we understand it is the space in the cup, not the concave ceramic structure, that has its own existence, identity and value. Simplicity is the foundation of design, not the goal or outcome. It is the controlled multiplication and amplification of simplicity that creates complexity.

Stanton · 16 May 2011

steve p. said: stupid rambling snipped A good intuition will lead to answers to the above questions. However, premature rejection/denial of the possibility/probability is (to put it mildly)imprudent and unjustified in light of the findings regarding bacterial invasion behavior.
Have you actually done any labwork to suggest bacteria are intelligent and or have their own civilization? No? Then why do we need to follow your inane suggestions if you are totally unwilling to provide us with actual evidence?
IOW, your refusal to follow the evidence where it leads hinders YOUR ability to understand what is actually happening.
Appealing to ignorance and appealing to the possibility that children's cartoons about intelligent microorganisms that organize themselves into one-celled parodies of humans do not constitute as "evidence."
We are not the only smart cookies on the planet. Even 'lil bitty 'isms like bacteria possess intelligence. Remarkable intelligence. Since when did you believe that only organisms with brain stems and a cerebrum have dibbs on intelligence.
Again, have you done any actual research or labwork to determine that bacteria are intelligent? Or is this more of your moronic navel contemplation that you want us to blindly swallow?
Your philosophy is more of a hinderance than a vehicle.
Project, much?

Stanton · 16 May 2011

Steve P., if intelligence and design are so apparent in nature, then how come Intelligent Design proponents are so hesitant to scientifically demonstrate how to look for and research this magical Intelligence?

Why is it that Intelligent Design proponents, like yourself, demonstrate themselves to be simultaneously scientifically illiterate and totally hateful, disdainful of science, yet, constantly demand that their words be taken as sacred, unimpeachable science-gospel?

DS · 16 May 2011

Steve:

So that would be a no, you have no examples of bacteria "actively seeking mutations", you have no mechanism whereby this could occur, you have no reason why this should occur and you have no evidence that this has ever occurred.

There is a vast literature containing elegant experiments that have rigorously tested the hypothesis of random mutations. You on the other hand got nothin. I would advise you to increase your knowledge.

Oh and substituting misconceptions for knowledge and then telling other that their philosophy is a hinderance is just plain hypocritical. Now why am I not surprised.

Science Avenger · 16 May 2011

steve p. said: SA, denying design in nature is like denying yourself. We do observe foresight -repair means a genome knows it needs to make an adjustment or die.
Jesus tapdancing Christ, repairing something after it is damaged is HINDSIGHT! The "after" is the hint. To be "fore" it needs to be, you know, BEFORE.
It may not know in the way humans know, but nevertheless it must know. Otherwise, it couldn't act on a mistake and correct it. To reject this is to outright reject basic logic. Happens alot here.
Nothing logical (other than circularly so) or scientific about any of that. It's just a string of unsupported assertions assuming that which you can't prove - that action requires knowledge.
True, we haven't observed blueprints because they are not material but natural nonetheless.
And you know this how exactly?
Simplicity is the foundation of design, not the goal or outcome.
Bullshit. Limited beings working with limited resources, energy, and time have simplicity as the goal/outcome in almost everything they do, and for the most logical of reasons: the simpler the design, the fewer resources consumed, and the more production of whatever it is that can be made. The redundant, inefficient complexity we observe in nature is the best evidence for no design we could have. It's the opposite of what known designers do. Only in Imaginary Steve Infinite Resource Happyland could it be otherwise.

steve p. · 17 May 2011

You guys are incredible. We use design every friggin' day of our lives.

We use design when we analyse human behavioral patterns so we know how to management employees. We use design when we set up an experiment. We use design when we look for patterns in data. We use design to make investment decisions. We use design to plan retirement, on and on.

I couldn't achieve anything I have done - assimilate into a foreign culture and become a native Chinese speaker, learn a new trade at the age of 36 and become very successful at it within 18 months, learn and succeed at currency trading, on and on - without using design principles and concepts.

You have to be mad to think design in not imbedded in life. You have to be completely irrational to assert a dichotomy between (designing) Man and (non-designing) nature.

Oh, but I get it. Emergent properties. That 'must have' intellectual salve that smoothes and soothes all contradictions.

How many of you are actually applying Darwinian principles in your daily lives? If so, best of luck. You will need lots and lots of it.

Design is fact. Design is success. Design is life.

There are no coincidences, except in a reductionist Darwinian world.

mrg · 17 May 2011

steve p. said: We use design when we analyse human behavioral patterns so we know how to management employees. We use design when we set up an experiment. We use design when we look for patterns in data. We use design to make investment decisions. We use design to plan retirement, on and on. I couldn't achieve anything I have done - assimilate into a foreign culture and become a native Chinese speaker, learn a new trade at the age of 36 and become very successful at it within 18 months, learn and succeed at currency trading, on and on - without using design principles and concepts. You have to be mad to think design in not imbedded in life. You have to be completely irrational to assert a dichotomy between (designing) Man and (non-designing) nature.
I'm convinced. All organisms were actually designed by us humans.

DS · 17 May 2011

Steve,

If bacteria can "actively seek mutations", how about you? Are you smarter than a bacteria? Tell you what, why don't you actively seek a mutation that gives you feathers. That shouldn't be so hard. You don't have to actually develop wings and fly, all you need is some feathers. You already have the genes to make the proteins, all you need to do is duplicate them and modify them a little. Her, I'll make it easier for you. You don't have to actually change every cell in your body, just one gamete. Then, all you have to do is g=have a child with feathers. In fact, have as many as you want. We'll wait.

What? You think that is silly? Well now you know howe everyone feels about your antiquated, vitalistic, supernatural nonsense. You can stick your head in the sand and ignore two thousand years of scientific progress, or you can join the real world. No one cares which you choose.

Fair warning, if you persist in disrupting this thread with off topic crap, the bathroom wall awaits. Now, got any explanation for the fifty intermediate penguin species? You did watch the video didn't you?

DS · 17 May 2011

Steve wrtote:

"FYI, bacteria are known to coordinate an attack on their host. They multiply but do not infect the host until a threshold number has been reached. The stay in contact to signal their numerical condition. When the target number is reached, communication/signalling increases, and subsequently the invasion of the host begins.

Tell me, DS? How do these bacteria communicate? How are they able to calculate their own numbers? How do they signal a command? Which one(s) do the signalling? Do we need answers to them to understand what is happening? No, we want them to be sure. But the absence of answers to the details does not prevent us from recognizing that in fact they are doing just that, communicating, calculating, deciding, responding, etc."

Bacteria communicate by chemicals. Scientists doing real research discovered this many years ago. If anyone is interested in any details, here are a few references:

Applied Environmental Microbiology (2001) 67(2)575-585

Journal Of clinical Microbiology (2003) 172(9):1288-1296

PNAS (2003) 100(S2):14559-14554

See, nothing intelligent, supernatural or magical about it. And of course it has nothing whatsoever to do with any claims about "actively seeking mutations".

Same old creationist routine. Pick some seemingly amazing aspect of nature, claim it means that puny humans can't possibly understand how it works so therefore it must mean GODDIDIT. How boring. The problem is that we really do need to understand how bacteria communicate in order to fight diseases. Assuming that bacteria are intelligent and just walking away is only going to result in more deaths. Denying the knowledge we do have about how bacteria evolved and continue to evolve is the only productive approach. That's why we call the approach Steve takes the Dark Ages. That's why nearly everyone has moved on since then, except apparently Steve.

DS · 17 May 2011

... not a productive approach.

Science Avenger · 17 May 2011

steve p. said: You have to be mad to think design in not imbedded in life. You have to be completely irrational to assert a dichotomy between (designing) Man and (non-designing) nature. Design is fact. Design is success. Design is life. There are no coincidences, except in a reductionist Darwinian world.
Assertion, assertion, assertion. You sound like CS Lewis after a bit too much coffee. To each assertion, we'll keep asking the same questions: How do you know that? Where is your evidence? What is the mechanism for these design claims of yours. When and how does it happen? How can you distinguish between design and non-design? No answers, no persuasion, simple as that. But being horrifically closed-minded whilst accusing others of same at least has some entertainment value. Try this at your next business meeting, let us know how it goes.

Dale Husband · 17 May 2011

Good grief! Is this steve p really as delusional as he appears to be? He ASSERTS that we can SEE evidence of DESIGN under the microscope. If he was referring to the bacterial flagellum, that might make sense. But resistance to antibiotics, not so much. BTW, what about resistance to pesticides by insects? Rachel Carlson predicted this in her book Silent Spring, yet she, as far as I know, didn't believe in Intelligent Design. Indeed, resistance to antibiotics by bacteria and resistance to presticides by insects are basic predictions of natural selection. NOT INTELLIGENT DESIGN! So steve p is promoting FRAUD, like every other stupid Creationist who barges in here!

Henry J · 17 May 2011

Of course people use design when doing things.

That has nothing to do with whether life prior to us was deliberately engineered by somebody or something.

Sheesh.

Hercules Grytpype-Thynne · 23 May 2011

All this commentary without a single mention of the classic Bloom County series on "Penguin Evolution vs. Scientific Penguinism"?
Penguin Evolution is a fib!
(That may be where Byers gets his material.)

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Henry J · 29 May 2011

Oh wonderful - spam trying to sell ways of dealing with spam! :p

mrg · 29 May 2011

Henry J said: Oh wonderful - spam trying to sell ways of dealing with spam! :p
Oh come on. Haven't you run into "free virus checks" yet?

Tyson F. Gautreaux · 6 June 2011

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