Bjørn Østman at
Pleiotropy describes new research in
Science that shows how duplicated genes can evolve to perform new functions. It presents
... a new model/mechanism by which duplicated genes can retain the selection pressure to not succumb to deleterious mutations. They call it the innovation-amplification-divergene model (IAD).
Basically,
IAD works like this: A gene initially has one function only (A). Then some genetic changes makes it also have a new function, b, which at first is not of too great importance. Then some environmental change favors the gene variants with the minor b-function (the innovation stage). This is then followed by duplication of the gene, such that there are now more than one copy that carries out A and b (the amplification stage). At this stage there is selection for more b, and at some point genetic changes in one of the copies results in a gene that is better at the new function, B. At this point, selection for the genes that do both A and b is relaxed, because the new gene (blue) carries out the new function. The original gene then loses the b function, and we are left with two distinct genes.
Michael Behe, of course,
scoffs. Because the researchers did some manipulations that created conditions favorable to the evolution of the new function, Behe claims that
Needless to say, this ain't how unaided nature works -- unless nature is guiding events toward a goal.
Shucks. I guess every experimental manipulation ever performed has been an invalid method of studying some process. But as a PT crew member pointed out on the back channel, "this kind of shit happens all the time in nature." See, for example,
Gene duplication and the adaptive evolution of a classic genetic switch or
Escape from adaptive conflict after duplication in an anthocyanin pathway gene.
86 Comments
https://me.yahoo.com/a/JxVN0eQFqtmgoY7wC1cZM44ET_iAanxHQmLgYgX_Zhn8#57cad · 12 November 2012
Well see, you have to do experiments if evolution is going to be science (never mind that they never do a sound test for "design"), but everything's thrown off if you actually use controls and variables. Because, uh, that's using your brain--I guess we'd have to hire brainless IDiots to do it all, and since nothing would make sense that way,...
Of course they don't care about experiments, they're doing religion. Religion doesn't need experiments because it's not in doubt (or they'd be sinning) in their minds.
Glen Davidson
Chuck Morrison · 12 November 2012
You see, there is always an intelligent designer behind experiments. Therefore, all experiments prove an intelligent designer.
QED.
mandrellian · 12 November 2012
Cue: incoherent medieval troll appearance and subsequent Wall banishment in 3, 2 ...
Chris Lawson · 13 November 2012
Funny. Just this morning on the previous thread I was saying that even if Behe's test of evolution was demonstrated in the laboratory, Behe would dismiss the evidence because it was not natural...and then -- BING! -- right on cue...
DS · 13 November 2012
Not only did the new function evolve, but it did so in just three thousand generations. A dramatic demonstration of the power of gene duplication in the evolution of novel traits. And of course, there is absolutely no reason why the same mechanism couldn't work for more complex traits as well.
It;s almost as if the entire scientific community is conspiring to make Behe look bad. Or maybe he just always chooses the wrong side of every issue.
DS · 13 November 2012
Not only did the new function evolve, but it did so in just three thousand generations. A dramatic demonstration of the importance of gene duplication in the evolution of novel traits. Of course, the same mechanism would work for more complex traits as well.
It's almost as if the entire scientific community is conspiring to make Behe look bad. Or maybe he just chooses the wrong side of every issue.
Kevin B · 13 November 2012
DS · 13 November 2012
This comment has been moved to The Bathroom Wall.
parictis · 13 November 2012
Moo Moo, I read the entire paper. And I learned that there is a model that explains the origin of new gene function without relaxed selection, which is important to avoid the production of pseudogenes. They also verified the model histidine/tryptophan specialization in using Salmonella. More here.
apokryltaros · 13 November 2012
This comment has been moved to The Bathroom Wall.
apokryltaros · 13 November 2012
j. biggs · 13 November 2012
ogremk5 · 13 November 2012
I've had the "intelligent design" of an experiment discussion with IDiots before. They really don't have a clue how to do science.
First, if the answer was known by the experimental designer, then there wouldn't be a lot of point in doing the experiment would there.
Second, even well designed experiments can produce unexpected data. If this wasn't the case, then every casino game engineer would be a multi-billionaire. They designed the roulette wheel, therefore, they know what every spin will be right?
Third, experiments are designed to reduce the uncertainty and ambiguity of the experiment. Throwing a bunch of random chemicals and adding random amounts of outside influences (water, electricity, heat, etc) may produce something interesting, but how and why? A well designed experiment reduces the uncertain part to one variable that is, in turn, controlled by one independent variable. If you experiment with a pendulum, you don't vary the length of the string, the mass of the bob, and the height you release it from and then try to figure out the difference in period and or the difference in g in the area. No, you intelligently change on aspect a time, in order to determine that aspect's influence on one and only one other aspect (length of string and period, for example).
Experiments that are not intelligently designed are useless. However, as shown, this does not mean that all experiments are evidence of intelligent design in the rest of the universe. It is evidence that humans are intelligent and can design a valid experiment that produces useful, unambiguous, and certain results. That's all.
If one wants to extrapolate this concept to Intelligent Design of the universe and every living thing in it, the one should first find the Intelligence that designed everything and ask that Intelligence why they did such a piss-poor job in designing the experiment that is our universe.
Starbuck · 13 November 2012
I like pigliucci's analogy. Experiments are to evolving life as a telescope is to galaxies and stars.
DS · 13 November 2012
Starbuck · 13 November 2012
You'll never hear a creationist say, telescopes are intelligently designed, therefore those galaxies are an artifactual byproduct of the designed telescope!
Rando · 13 November 2012
raven · 13 November 2012
raven · 13 November 2012
harold · 13 November 2012
Moo Moo -
Let's take it one step at a time.
Can gene duplication occur? Simple yes/no question. Answer this one question.
Rolf Aalberg · 14 November 2012
Rolf Aalberg · 14 November 2012
I was too cryptic; what I meant was a metaphor for what it would be like for people like Moo Moo to take the road you would lead them down.
ogremk5 · 14 November 2012
DS · 14 November 2012
Joe always makes the same mistake. He always thinks that he is more qualified to judge the experimental results than the real scientists who actually performed the research.. He is also obsesses with demanding that everyone read the entire paper, as if reading the abstract was somehow insufficient. At least he isn't pretending to be a scientist any more. Apparently he has somehow obtained a mail order law certificate and is now calling himself a lawyer. Of course he isn't any more a lawyer than he is a scientist.
His criticism of the research are of course completely invalid. Once again, the authors, editors and reviewers all disagree with him. But he doesn't care. He just goes merrily on his way making ignorant claims and trying to denigrate that which he doesn't understand. At the end of the day all he has is his own incredulity, which is of course completely worthless.
We have known about the importance of gene duplication for forty years now. Some people just can't seem to get it through their heads. The telescope didn't make the stars, it simply reveals them to us, just like this experiment.
eric · 14 November 2012
ogremk5 · 14 November 2012
j. biggs · 14 November 2012
DS · 14 November 2012
eric · 14 November 2012
W. H. Heydt · 14 November 2012
ksplawn · 14 November 2012
Moo Moo, why do you feel that evolution should be singled out among the sciences and put on hold when it comes to teaching it in public schools?
This is getting old, PTers. How many trolls are we going to have that just skip from thread to thread, refusing to answer direct and simple questions?
Flint · 14 November 2012
Sounds to me very much like Joe is a lawyer, because what lawyers do for a living, and what they are paid to do, is spin everything. To a True Lawyer, there's no such thing as empirical truth, there is ONLY spin, preference, positioning, and the like. There is never the "whole truth", only the half they are paid to make LOOK like the whole truth.
And this is done with very clear, specific concrete goals in mind. The last thing a criminal lawyer wants to hear is a confession from his client. He is not being paid to find out whodunnit, he's being paid to get his guy off. If he KNOWS his guy did it, and can convince a jury otherwise, he wins.
Someone like that will see spin everywhere. "Evolutionists" are nothing more than the lawyers for the opposition, spinning just as hard as he is. What matters isn't the biology itself, what matters is convincing the court of public opinion that your side is correct. Whether or not it IS correct is perhaps interesting, but not relevant.
apokryltaros · 14 November 2012
Richard B. Hoppe · 14 November 2012
I'm currently not able to moderate here in real time. I'll say that while Joe has been somewhat less disruptive than he usually is, it's getting out on the edge now. I leave the comments because they've elicited some informative responses, but he's just about worn out his welcome in this thread.
Richard B. Hoppe · 14 November 2012
And now we've decided to disable Moo Moo's ability to comment due to violation of our usage rules.
DS · 14 November 2012
Karen S. · 14 November 2012
Carl Drews · 14 November 2012
Just to review - the Science paper "Real-Time Evolution of New Genes by Innovation, Amplification, and Divergence" demonstrates the addition of new genetic information, right? New, useful, and functional genetic information? There is no way Ken Ham can crawl out of this one?
I can always use more good scientific references for my site.
DS · 14 November 2012
harold · 14 November 2012
Apparently it actually was Joe.
Anyway, any other creationist is welcome to answer my simple question - does gene duplication happen, yes or no?
Also, "artificial" section IS natural selection.
In fact, all "artificial" products ARE non-supernatural.
The term natural is used colloquially to contrast products, often considered superior, which use more directly biological ingredients, to other types of products.
E.g. a 100% cotton shirt may be deemed more "natural" than a shirt containing some polyester fibers. But in fact, they are both "natural" products, as opposed to "miraculous", "divine", or "supernatural" products.
When fox behavior selects for faster rabbits, that is natural selection. When human behavior selects for cows that give more milk, that is natural selection. It is true that we select for the result we want - in this example - and foxes select for a result they don't want - in this example. It's still all selection, and it's still all natural.
As has been noted, domestication can be thought of as symbiosis or commensalism, rather than predation. That is true, but it is still natural selection. The behavior of one species leads to the selection for traits in another species.
Rando · 14 November 2012
Karen S. · 14 November 2012
Just Bob · 14 November 2012
harold · 14 November 2012
Chris Lawson · 14 November 2012
The only difference between "natural" and "artificial" selection is that in the latter, breeders choose some of the selection pressures. Even then, the underlying evolutionary forces are mostly natural. There are still failed pregnancies and fatal congenital malformations that have nothing to do with human intervention, plus unintended consequences of breeding (e.g. hip dysplasia in dogs). Claiming that "artificial" selection is completely unrelated to natural selection is like claiming that beer brewing has nothing in common with natural fermentation.
Henry J · 14 November 2012
apokryltaros · 14 November 2012
MichaelJ · 15 November 2012
TomS · 15 November 2012
https://me.yahoo.com/a/XRnHyQl8usUn8ykD1Rji0ZXHNe.9lqmg3Dm7ul96NW4vxpbU3c_GLu.k#d404b · 15 November 2012
raven · 15 November 2012
DS · 15 November 2012
Rando · 15 November 2012
Henry J · 15 November 2012
stevaroni · 15 November 2012
Mike Elzinga · 16 November 2012
harold · 16 November 2012
Paul Burnett · 16 November 2012
DS · 16 November 2012
The way I like to look at it is this. Laboratory experiments tell us nothing about what actually happened in nature, but they tell us a lot about what can happen in nature, given the right conditions.
Creationists like to try to deny this. They won't accept laboratory experiments because they are "unnatural" and they won't accept examples from nature because they are "unobserved" or "uncontrolled". Basically, they ain't gonna believe nothin they don't wanna and there's nothin you can do about it.
The best approach is to show the concordance between laboratory experiments and observations in nature. Show that the laboratory results are consistent with the hypothesis that explain the observations from nature. Show that the model can be used to accurately predict the results from both laboratory experiments and nature. That's what this paper does. IT test the predictions of a hypothesis and finds that the results are consistent with the hypothesis. It doesn't demonstrate that this is the only mechanism, but it is a possible mechanism. And it explain some observations from nature.
Of course creationists won't be convinced, but who cares? At that point they are exposed as the biased science deniers that they are.
https://me.yahoo.com/a/JxVN0eQFqtmgoY7wC1cZM44ET_iAanxHQmLgYgX_Zhn8#57cad · 16 November 2012
https://me.yahoo.com/a/JxVN0eQFqtmgoY7wC1cZM44ET_iAanxHQmLgYgX_Zhn8#57cad · 16 November 2012
We should perhaps talk of 'artificial natural selection' or some such thing when we simply create the conditions that select for certain traits that we want (when it's not just experimenting with "natural selection," that is).
So that if I'm trying to create an antibiotic-resistant strain of bacteria simply by growing those bacteria in increasing quantities of that antibiotic--and not selecting the reproducers by artifice--that would be artificial natural selection.
Glen Davidson
ogremk5 · 16 November 2012
or just "selection"
harold · 16 November 2012
It's really not complicated. "Artificial selection", which is to all extents and purposes a needlessly fancy term for "breeding", is a type of natural selection.
Can it be distinguished from other types of natural selection? Yes, it usually can. And walnuts can usually be distinguished from other types of tree nuts, but they're still tree nuts.
Creationists try to discount many otherwise undeniable examples of evolution through genetic diversity and selection, by pretending that "artificial selection" is in some way unnatural or magical.
Creationists themselves can't be changed but their slogans do confuse well-meaning third parties. For the benefit of third parties, it helps to clarify things.
Human breeding of domestic animals and plants is a uniqute type of evolution, but it's still evolution, and the selection involved is still natural.
W. H. Heydt · 16 November 2012
TomS · 16 November 2012
Paul Burnett · 16 November 2012
Paul Burnett · 16 November 2012
"Out of sight, out of mind" becomes "Invisible and insane."
PT needs a post-submission editing function...
https://me.yahoo.com/a/JxVN0eQFqtmgoY7wC1cZM44ET_iAanxHQmLgYgX_Zhn8#57cad · 16 November 2012
Richard B. Hoppe · 16 November 2012
"Artificial" selection and "natural" selection differ not in the populations under selective pressure in one or the other, but only in the source of the selective environment. What happens in the populations under selective pressure--differential reproductive success as a function of the adaptiveness of varying traits in a given selective environment--does not differ. Mutations that are random with respect to the selective environment, whether or not that environment includes human "desires", are successful or not in that selective environment depending on their effect on the relative reproductive rate of variants with and without the mutations. Gene frequencies change, due both to the selective environment and drift, and populations shift on the fitness landscape. That humans are tinkering with the shape of the fitness landscape doesn't alter the core process.
Just Bob · 16 November 2012
Question for the pros in biology, ethology, philosophy or anything pertinent:
Let us stipulate that artificial selection is the INTENTIONAL selection of organisms with desired traits in order to proliferate or enhance those traits in offspring. I suspect that humans were enhancing the transmission of useful traits before they realized they were doing that, or that they could do it on purpose.
But that aside, here's the question: Are there any other species that might be said to practice artificial selection of other organisms in their environment, i.e., selecting organisms for survival and reproduction in such a way that the selected-upon organisms are gradually improved from the point of view of the selecting species? (A fox selecting for faster rabbits wouldn't count, because faster rabbits are not better from the fox's point of view.)
I realize that many would balk at assigning intention or purpose to non-human animals, but let's be generous for the sake of argument. If humans many thousands of years ago were practicing artificial selection when they decided to keep around the most tractable of the wolf pups (and probably ate the others), without really realizing that over generations they were selecting for and fixing genes for tameness, then might some other species be doing something similar?
Richard B. Hoppe · 16 November 2012
Some ant species 'farm' fungi. It's not clear to what degree (if any) traits of the fungi are due to selection practiced by the ants, though I wouldn't be amazed if it were the case.
The fungi apparently have some traits, The ants apparently use chemical agents, like chemicals that fight microfungal 'weeds,' that might be candidates for the practice of (unconscious) selection by the ants. See here for an example.(Edited to make it clear that the fungi don't produce the agents, but rather apparently the ants use anti-weed bacterial agents.)
Just Bob · 16 November 2012
I was thinking of social insects as possible candidates. Might not bees be selecting for flowers that are more beneficial to the bees by selectively pollinating those that offer the most nectar or are otherwise more attractive?
Come to think of it, don't many animals select for improved fruit by selectively eating the "best" fruit, and thereby distributing the seeds?
harold · 16 November 2012
KlausH · 16 November 2012
Just Bob · 16 November 2012
I guess my point is the same as others have been getting at: "artificial" and "natural" selection are a distinction without a real difference. If humans unintentionally modifying wolves, wild cattle, sheep, etc. into early domesticated breeds is "artificial" selection, then so must the unintentional modification of flowers, fruits, and probably many more things by other animals be "artificial" selection. The modification in both cases benefits the modifier, but is done entirely without a goal in mind of 'improving the breed'.
As others have said: it's all natural.
Henry J · 16 November 2012
Henry J · 16 November 2012
Henry J · 16 November 2012
Chris Lawson · 17 November 2012
The term "natural selection" was invented by Darwin because he and everyone else knew about selective breeding, and his argument was that selective breeding also takes place in natural environments. Hence, natural selection. His entire point was that natural selection and selective breeding were the same process.
harold · 17 November 2012
harold · 17 November 2012
whoops...
The bait and switch between “artificial” and “miraculous” because each is “the opposite of natural” is a different, older game, frequently played by overt YEC types, as here.
gnome de net · 17 November 2012
https://me.yahoo.com/a/JxVN0eQFqtmgoY7wC1cZM44ET_iAanxHQmLgYgX_Zhn8#57cad · 17 November 2012
Just Bob · 17 November 2012
harold · 18 November 2012
harold · 18 November 2012
Glen Davidson -
I should add, I really don't think we have a dispute here.
I completely agree that the results of human breeding, whether domestic maize or delicate transgenic mice that can only survive in a special human-created environment, tend to be different from the results of other selective forces.
However, I'm sure we both agree that...
1) The process of human deliberate breeding is, among other things, A) natural and B) selection.
2) The fact that humans can "design", and that we can recognize the "designs" of other humans, including but not limited to products of breeding, does not imply that the bacterial flagellum, Adam and Eve, the first replicating cell on earth, or anything else, had to be "designed" by a deity.
I'm sure you agree with these points, so beyond that, stylistic disputes about the use of the term "artificial selection" have reached an impasse.